Table 3

Change in the SOBDA (A) weekly score by PGAC responders, and (B)last treatment week score by assessment responders at visit 3

(A)
	Day 8	Day 15	Day 22	Day 29	Day 36	Day 43
PGAC responders (n)	105	91	83	62	77	31
PGAC non-responders (n)	188	212	216	223	200	88
LS mean difference in SOBDA scores between groups (95% CI)	0.24 (0.18 to 0.31)	0.12 (0.06 to 0.19)	0.11 (0.06 to 0.16)	0.11 (0.06 to 0.17)	0.13 (0.08 to 0.18)	0.06 (−0.03 to 0.15)
p Value*	<0.001	<0.001	<0.001	<0.001	<0.001	NS

(B)
	CGI-C	CRQ-SAS dyspnoea domain	Clinician-completed mMRC	Patient-completed mMRC	PGAC
Responders (n)	120	117	91	92	45
Non-responders (n)	181	184	210	209	106
LS mean difference in SOBDA scores between groups (95% CI)	0.24 (0.14 to 0.34)	0.30 (0.21 to 0.40)	0.03 (–0.08 to 0.15)	0.08 (–0.02 to 0.19)	0.08 (–0.07 to 0.23)
p Value†	<0.001	<0.001	NS	NS	NS

*Comparison of SOBDA scores (non-responders minus responders) based on analysis of covariance adjusted for age, gender and previous week's SOBDA score.
†Comparison of SOBDA scores (non-responders minus responders) based on Analysis of Covariance adjusted for age, gender and baseline SOBDA weekly score.
CGI-C, Clinician Global Impression of Change; CRQ-SAS, Chronic Respiratory Disease Questionnaire self-administered standardised version; LS, least squares; mMRC, modified Medical Research Council; NS, not significant; PGAC, Patient Global Assessment of Change; SOBDA, Shortness of Breath with Daily Activities.