Table 1

Study population characteristics*

All patients (n=242)Genotype 1 (n=166)Genotypes 2/3 (n=64)
Age in years48 (43–54)48 (43–54)49 (43–54)
Male gender123 (51)88 (53)28 (44)
Race/ethnicity
 Caucasian113 (47)68 (41)44 (68)
 African-American76 (31)65 (39)5 (8)
 Hispanic34 (14)25 (15)9 (14)
BMI†28 (25–35)30 (25–35)27 (25–32)
 <2558 (24)35 (21)15 (25)
 25–3085 (36)57 (35)25 (41)
 >3094 (40)72 (44)21 (34)
Diabetes40 (17)32 (19)7 (11)
AST (U/L)57 (42–91)60 (42–93)56 (42–84)
ALT (U/L)63 (48–103)66 (47–103)62 (50–100)
Albumin (g/dL)4.3 (4.0–4.6)4.3 (4.0–4.6)4.4 (3.1–4.6)
WCC (×103/µL)‡6.5 (5.2–7.8)6.6 (5.2–7.8)6.4 (5.2–7.7)
Haemoglobin (g/dL)14.7 (13.7–15.9)14.7 (14.0–15.9)14.8 (13.5–16.0)
Platelet count (×103/µL)203 (148–250)201 (140–252)209 (154–249)
HCV virus (×103 IU/mL)§500 (272–950)473 (274–850)569 (252–1480)
Biopsy with cirrhosis¶36/172 (21)29/129 (22)6/30 (20)
Clinical cirrhosis**40 (17)29 (17)11 (17)
Time (months)††
 Before start9 (4–16)9 (5–21)8 (4–11)
 After start64 (24–95)61 (21–92)62 (34–98)
Deaths43 (18)34 (20)9 (14)
  • *Results are median (IQR in parentheses) or number (percentage in parentheses).

  • †Incomplete BMI data for 2 patients with genotypes 1 and 3 patients with genotypes 2/3.

  • ‡No complete blood count data in retrievable records for one patient with genotype 2 prior to therapy. On day 8, Hb 15.3 g/dL, WCC 6700/µL and platelet count 236 000/µL.

  • §No retrievable data for two patients, one with genotype 1, one with genotype 3.

  • ¶Biopsy results are number with cirrhosis/number of patients who were biopsied (percentage with cirrhosis in parentheses). Fewer patients with genotypes 2 and 3 were biopsied.

  • **Radiological evidence or complications as defined in methods. These patients did not undergo liver biopsy.

  • ††Time in the Liver Clinic before the start of therapy and time in the hospital systems after the start of therapy. Records of clinic appointments are available in an electronic health record starting in 1998. Records for both Parkland Health and Hospital System encounters and the University Hospitals of UT Southwestern Medical Center are aggregated in a clinical data repository.

  • ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; Hb, haemoglobin; HCV, hepatitis C virus; WCC, white cell count.