HR | 95% CI | p Value | |
---|---|---|---|
Age at RA diagnosis | 0.98 | 0.93 to 1.04 | 0.48 |
Age at ILD diagnosis | 1.08 | 0.99 to 1.17 | 0.057 |
Sex, male | 1.14 | 0.63 to 2.22 | 0.67 |
Smoking habit, yes | 1.70 | 0.87 to 4.35 | 0.13 |
UIP pattern on HRCT, yes | 1.74 | 0.97 to 3.12 | 0.06 |
PaO2 at ILD diagnosis | 1.05 | 0.98 to 1.11 | 0.15 |
%FVC at ILD diagnosis | 1.01 | 0.98 to 1.04 | 0.55 |
AE during observation period, yes | 2.47 | 1.39 to 4.56 | 0.003* |
Treatment for RA at final visit† or AE onset‡ | |||
Corticosteroids | 1.23 | 0.67 to 2.65 | 0.52 |
Immunosuppressant except for MTX | 0.69 | 0.32 to 1.27 | 0.25 |
MTX | 1.44 | 0.67 to 2.68 | 0.31 |
Other drugs | 0.76 | 0.36 to 1.41 | 0.40 |
*p < 0.05.
†In non-AE group.
‡In AE group.
AE, acute exacerbation; %FVC, predicted forced vital capacity; HRCT, high resolution CT; ILD, interstitial lung disease; MTX, methotrexate; PaO2, arterial oxygen pressure; RA, rheumatoid arthritis; UIP, usual interstitial pneumonia.