Table 3

Association of markers with baseline disease activity

Serum protein and RNA markers
	Serum IL-6			Serum sIL-6R			IL-6R 217489_s_at	IL-6ST 234967_at
End point	AMBITION	RADIATE	Pooled DMARD-IR	AMBITION	RADIATE	Pooled DMARD-IR	RADIATE	RADIATE
DAS28
N	480	322	2286	577	423	2620	217	217
β	0.209	0.257	0.201	–0.007	0.075	0.054	0.109	–0.04
r²	0.051	0.072	0.044	0	0.006	0.003	0.013	0.002
p	<0.0001	<0.0001	<0.0001	0.8478	0.1018	0.0044	0.09	0.54
TJC
N	481	327	2305	580	428	2642	217	217
β	–0.186	1.455	0.138	–0.154	1.28	0.054	0.27	1.276
r²	0	0.009	0	0	0.007	0	0	0.007
p	0.7742	0.0938	0.6611	0.7967	0.0889	0.8558	0.79	0.2140
SJC
N	481	327	2305	580	428	2642	217	217
β	0.247	1.421	0.813	–0.679	–0.069	0.52	–0.864	0.218
r²	0	0.018	0.006	0.004	0	0.002	0.008	0
p	0.6279	0.0158	0.0003	0.1424	0.8938	0.013	0.1950	0.7440
ESR
N	481	327	2299	580	428	2635	217	217
β	0.19	0.172	0.151	0.039	–0.003	0.023	0.164	–0.132
r²	0.088	0.091	0.055	0.004	0	0.001	0.082	0.053
p	<0.0001	<0.0001	<0.0001	0.132	0.9158	0.0672	<0.0001	0.0007
CRP
N	481	327	2305	580	428	2642	217	217
β	0.363	0.429	0.35	0.007	0.019	0.019	0.228	–0.145
r²	0.288	0.358	0.309	0	0.001	0.001	0.089	0.036
p	<0.0001	<0.0001	<0.0001	0.8103	0.5935	0.1242	<0.0001	0.005
HAQ
N	480	324	2165	579	425	2465	217	217
β	0.085	0.145	0.084	0.002	0.074	0.024	0.048	–0.103
r²	0.019	0.062	0.018	0	0.016	0.002	0.007	0.031
p	0.0022	<0.0001	<0.0001	0.933	0.0089	0.0504	0.22	0.009

All results for serum markers are shown. For RNA, the probe sets within each gene were strongly correlated. One probe set each in IL-6R and IL-6ST is shown. For DNA, only associations with raw p<0.01 (tier 1) and FDR ps<0.05 (tiers 2 and 3) were shown. FDR was calculated within the population (white or all) and within the tier.
β, regression coefficient, representing the difference in the end point corresponding to SD in marker value; Chr, chromosome; CRP, C reactive protein; DAS28, Disease Activity Score using 28 joints; DMARD, disease-modifying antirheumatic drug; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; IL-6ST, IL-6 signal transducer; IR, inadequate responder; MAF, minor allele frequency; MTX, methotrexate; SJC, swollen joint count; TCZ, tocilizumab; TJC, tender joint count.