Table 2

Association between mental health status (Mental Component Summary score from the Short-Form 12 V.2) and subsequent cardiovascular events or death, with sequential adjustment for potential confounders

HR (95% CI)
Adjusted variables*First quartile MCS (102/220)†Second quartile MCS (80/220)†Third quartile MCS (63/220)†Fourth quartile MCS (32/220)†
Age3.53 (2.36 to 5.27)2.67 (1.77 to 4.03)2.09 (1.36 to 3.19)1 (reference)
Sociodemographic characteristics‡3.56 (2.35 to 5.38)2.57 (1.69 to 3.92)2.06 (1.34 to 3.16)1 (reference)
MRC dyspnoea score ≥32.74 (1.76 to 4.26)2.30 (1.50 to 3.53)1.96 (1.27 to 3.00)1 (reference)
Comorbidity§2.65 (1.70 to 4.13)2.29 (1.50 to 3.51)1.99 (1.29 to 3.05)1 (reference)
Secondary prophylactic medication2.77 (1.78 to 4.31)2.32 (1.51 to 3.56)1.95 (1.27 to2.99)1 (reference)
Smoking status2.76 (1.76 to 4.31)2.31 (1.51 to 3.56)1.96 (1.27 to 3.01)1 (reference)
Physical activity2.47 (1.56 to 3.91)2.25 (1.47 to 3.46)1.89 (1.23 to 2.91)1 (reference)
HADS-A/D score ≥82.26 (1.37 to 3.73)2.15 (1.38 to 3.35)1.87 (1.21 to 2.88)1 (reference)
  • *Each model includes the variables from the preceding row so that the final model includes all the variables listed in this table.

  • †Number of outcomes/number of persons in quartile.

  • ‡Sex, cohabitation status, education, labour market status.

  • §History of stroke, diabetes mellitus or heart failure.

  • MCS, Mental Component Summary; HADS-A/D, Hospital Anxiety and Depression Scale-Anxiety/Depression; MRC, Medical Research Council.