Table 5

Effects of time-varying risk factors individually on DAS28 scores over 1 year of study—univariate regression

	DAS4v
	β	95% CI	p Value
Female	0.45	0.09 to 0.81	0.014
Age	0.001	−0.13 to 0.02	0.82
Smoking
Ex-smokers vs non-smokers	−0.27	−70 to 0.16	0.22
Current smokers vs non-smokers	−0.48	−0.91 to -0.06	0.026
SBP	0.10	0.08 to 0.20	<0.001
DBP	0.10	0.04 to 0.20	0.004
Lymphocyte	0.04	−0.09 to 0.17	0.55
Neutrophil	0.16	0.10 to 0.22	<0.001
ESR	0.03	0.03 to 0.04	<0.001
CRP	0.02	0.01 to 0.02	<0.001
LFT-AST	−0.004	−0.01 to 0.003	0.25
LFT-ALT	−0.003	−0.009 to 0.004	0.44
Weight×CRP	0.002	0.001 to 0.003	<0.001
Weight×ESR	0.004	0.003 to 0.005	<0.001
Oral or IA steroid	0.66	0.34 to 0.99	p<0.01
Anti-CCP>6	0.001	−0.001 to 0.002	0.36

Regression co-efficient at each time point for RF=0.
ALT, alanine aminotransferase; CRP, C reactive protein; DBP, diastolic blood pressure; ESR, erythrocyte sedimentation rate; IA, intra-articular; LFT, liver function test; SBP, systolic blood pressure.