Soft drink consumption and rate of OA progression measured by the change of medial compartment joint space narrowing score (JSN, OARSI grades 0–3)
| Soft drinks (times/week) | Men | Women | ||||
|---|---|---|---|---|---|---|
| N | HR (95% CI) | p trend | N | HR (95% CI) | p trend | |
| Overall | ||||||
| None | 202 | Referent | 485 | Referent | ||
| ≤1 | 439 | 1.56 (1.13 to 2.16) | 537 | 0.80 (0.62 to 1.02) | ||
| 2–4 | 140 | 1.55 (1.02 to 2.35) | 145 | 1.09 (0.77 to 1.54) | ||
| ≥5 | 107 | 2.05 (1.32 to 3.19) | 0.002 | 94 | 0.81 (0.52 to 1.26) | 0.539 |
| Non-obese | ||||||
| None | 113 | Referent | 279 | Referent | ||
| ≤1 | 266 | 1.66 (1.05 to 2.63) | 277 | 0.71 (0.49 to 1.03) | ||
| 2–4 | 85 | 1.45 (0.80 to 2.60) | 60 | 1.03 (0.59 to 1.80) | ||
| ≥5 | 53 | 2.30 (1.22 to 4.34) | 0.025 | 32 | 0.86 (0.41 to 1.84) | 0.559 |
| Obese | ||||||
| None | 89 | Referent | 206 | Referent | ||
| ≤1 | 173 | 1.58 (0.99 to 2.52) | 260 | 0.88 (0.63 to 1.25) | ||
| 2–4 | 55 | 1.77 (0.96 to 3.28) | 85 | 1.17 (0.74 to 1.84) | ||
| ≥5 | 54 | 1.90 (1.03 to 3.52) | 0.033 | 62 | 0.87 (0.50 to 1.52) | 0.965 |
*Adjusted for age, race, education, marital status, household income, employment, follow-up time, BMI, knee injury and knee surgery, smoking, milk and juice intake, total energy intake, baseline KL grade.
BMI, body mass index; KL, Kellgren-Lawrence JSN, joint space narrowing; OA, osteoarthritis; OARSI, Osteoarthritis Research Society International.