Table 5

MI HRs comparing participants in each of the three RCT datasets to WHI OS participants

OutcomeDatasetUnadjustedAdjusted†
HRχ2HRχ2
Patients not on HT (N=78 069)
RCT E+P0.970.151.206.14
RCT E alone1.43***24.981.37***18.69
RCT diet1.010.071.14**7.08
Patients on E+P (N=35 021)
RCT E+P2.43***97.231.53***19.08
RCT diet1.29*5.971.37**8.86
Patients on E-only (N=38 672)
RCT E only1.89***58.171.44***17.23
RCT diet0.990.001.040.22
  • *p<0.05.

  • **p<0.01.

  • ***p<0.0001.

  • †Covariables used for the adjustment are described in the text.

  • E+P, oestrogen plus progestin; HT, hormone therapy; MI, myocardial infarction; OS, observational study; RCT, randomised controlled trial; WHI, Women's Health Initiative.