Table 3

Associations between alcohol exposure and ADH1B rs1229984

Alcohol-exposure measureTotal NN of A allele carriersOR (95% CI)p Value
Total maternal alcohol consumption, prepregnancy41812110.61 (0.47 to 0.79)<0.001
Total maternal alcohol consumption at 18 weeks gestation41712100.66 (0.48 to 0.90)0.010
Maternal binge drinking (at 18 weeks)41692090.60 (0.38 to 0.96)0.031
Total maternal alcohol consumption at 47 months postnatally38241920.67 (0.52 to 0.87)0.003
Total paternal alcohol consumption in first 3 months pregnancy34071711.03 (0.77 to 1.37)0.854
Paternal binge drinking34461720.94 (0.71 to 1.24)0.663
  • OR for higher alcohol consumption for white-European women (or for their partners in the paternal analyses)—A allele carriers versus non-carriers.

  • ADH, alcohol dehydrogenase.