Putative potential molecular targets of the 2-arylpropanoic class in Mycobacterium tuberculosis based on homology of the human reported targets
| IBP/2-arylpropanoic acid molecular target in humans | Function in humans | Homologues in Mycobacterium tuberculosis H37Rv | Function in Mycobacterium tuberculosis | Homologues in Mycobacterium leprae | Homologues in Mycobacterium smegmatis |
|---|---|---|---|---|---|
| COX-1 | Cyclooxygenase 1 | No | – | No | MS6324 (Evalue 10-19) |
| COX-2 | Cyclooxygenase 2 | No | – | No | MS6324 (Evalue 10-19) |
| Presenilin-1 | Trans-membrane γ-secretasesubunit | No | – | No | No |
| APH-1A | γ-Secretase subunit 1A | No | – | No | No |
| PEN-2 | γ-Secretase subunit | No | – | No | No |
| NF-κB | Nuclear factor κ enhancer of activated B cells | No | – | No | No |
| APH-1B | γ-Secretase subunit 1B | Rv2276 (Evalue 0.0013) | Cytochrome P450–121 CYP121 | No | No |
| Nicastrin | γ-Secretase subunit | Rv3411c (Evalue 0.019) | Inosine-5-monophosphate dehydrogenase guaB2 | No | No |
| PPARG-1/2 | Peroxisome proliferator activated-receptor γ | Rv3146 (Evalue 0.007) | NADH-ubiquinone dehydrogenase subunit B | No | MS2062 (Evalue0.007) |
| RHO-GTPase | Rho GTPase | Rv2839c (Evalue 10-5) | Translation initiation factor IF-2 | ML1556 (Evalue 0.005) | MS0758 (Evalue 0.006) |
This table shows the homologous proteins found in mycobacterial organisms that share sequence similarity with recorded human targets of ibuprofen and other 2-arylpropanoic acids.