Table 2

Methodological quality assessment and risk-of-bias

Randomisation adequate?Allocation concealed?Groups similar at baseline?Patient blinded?Care provider blinded?Outcome ssessor blinded?Dropout rate described and acceptable?Intention to treat analysis?Co-interventions avoided or similar?Compliance acceptable?Timing outcome assessment similar?Report free of selective outcome reportingTotal
Wilkens et al30YesYesYesYesYesYesYesYesYesYesYesYes12
Tant et al31YesNoYesNoNoNoYesNoYesUnclearYesYes6
Leffler et al32unclearYesYesYesYesYesNoYesYesYesYesYes10
  • Risk-of-bias assessed using criteria from the CBRG.27 Studies rated as having a ‘low risk-of-bias’ when at least 6 of the 12 CBRG criteria have been met and it has no serious flaws.