Variables | Phase I | Phase II | Phase III | p Value |
---|---|---|---|---|
Number of patients | 1077 | 1148 | 1197 | |
Gestational age (weeks) (mean, SD) | 33.9 (4.5) | 33.6 (4.6) | 34.3 (4.7) | <0.01 |
Preterm infants <37 weeks (n, %) | 706 (66) | 773 (67) | 708 (59) | <0.01 |
Birth weight (g) (mean, SD) | 2237 (1007) | 2183 (993) | 2366 (1039) | <0.01 |
Low birth weight infants (n, %) | 657 (61) | 735 (64) | 667 (56) | <0.01 |
Very low birth weight infants (n, %) | 305 (28) | 321 (28) | 285 (24) | 0.02 |
Extremely low birth weight infants (n, %) | 121 (11) | 157 (14) | 142 (12) | 0.19 |
Average length of stay* (days) (mean, SD) | 18.5 (26.9) | 16.4 (24.8) | 14.7 (24.2) | <0.01 |
Need for invasive and non-invasive ventilation (days) (mean, SD) | 2.5 (8.2) | 2.2 (7.2) | 2.5 (9.1) | 0.60 |
Number of patient days CPAP (mean, SD) | 6.5 (14.5) | 5.5 (13.2) | 3.6 (9.0) | <0.01 |
*Note that many patients are transferred to a peripheral level II neonatal intensive care unit once stable.
CPAP, continuous positive airway pressure.