Reproductive hormone levels of young men from four cities in Japan
| Observed | Adjusted | ||
|---|---|---|---|
| Mean (SD) | Median (5–95) | Median (95% CI) | |
| FSH (U/l) | |||
| Entire study population | 2.5 (1.3) | 2.2 (1.1–4.9) | 2.3 (2.2 to 2.5) |
| Kawasaki | 2.7 (1.3) | 2.4 (1.1–5.2) | 2.4 (2.3 to 2.6) |
| Osaka | 2.5 (1.3) | 2.2 (1.1–5.0) | 2.3 (2.1 to 2.4) |
| Kanazawa | 2.3 (1.3) | 2.1 (1–4.4) | 2.1 (1.9 to 2.3) |
| Nagasaki | 2.3 (1.2) | 2.1 (0.9–4.4) | 2.1 (1.9 to 2.2) |
| p Value | p<0.0001 | ||
| Inhibin-B (pg/ml) | |||
| Entire study population | 202 (64) | 197 (110–314) | 190 (181 to 199) |
| Kawasaki | 207 (64) | 202 (113–322) | 191 (181 to 201) |
| Osaka | 214 (67) | 210 (117–336) | 193 (182 to 205) |
| Kanazawa | 191 (62) | 190 (104–304) | 177 (164 to 191) |
| Nagasaki | 188 (60) | 182 (103–286) | 176 (165 to 187) |
| p Value | p=0.003 | ||
| LH (U/l) | |||
| Entire study population | 3.2 (1.3) | 2.9 (1.5–5.6) | 2.7 (2.6 to 2.9) |
| Kawasaki | 3 (1.3) | 2.8 (1.4–5.3) | 2.7 (2.5 to 2.8) |
| Osaka | 3.5 (1.4) | 3.2 (1.8–6.4) | 3.0 (2.9 to 3.2) |
| Kanazawa | 3.3 (1.4) | 3.1 (1.6–5.8) | 2.8 (2.6 to 3.1) |
| Nagasaki | 2.9 (1.0) | 2.8 (1.5–4.9) | 2.6 (2.4 to 2.8) |
| p Value | p<0.0001 | ||
| Testosterone (nmol/l) | |||
| Entire study population | 25 (8) | 24 (14–39) | 26 (25 to 27) |
| Kawasaki | 26 (7) | 25 (15–39) | 26 (25 to 27) |
| Osaka | 27 (9) | 26 (15–42) | 27 (26 to 28) |
| Kanazawa | 22 (7) | 21 (12–35) | 23 (21 to 24) |
| Nagasaki | 22 (7) | 21 (13–36) | 23 (21 to 24) |
| p Value | p<0.0001 | ||
| SHBG (nmol/l) | |||
| Entire study population | 28 (11) | 26 (13–46) | 27 (26 to 28) |
| Kawasaki | 30 (11) | 29 (14–49) | 28 (27 to 30) |
| Osaka | 29 (11) | 27 (14–50) | 26 (25 to 28) |
| Kanazawa | 24 (9) | 23 (12–41) | 23 (21 to 24) |
| Nagasaki | 24 (9) | 23 (12–42) | 23 (21 to 24) |
| p Value | p<0.0001 | ||
| cFT (pmol/l)* | |||
| Entire study population | 607 (192) | 585 (326–949) | 638 (613 to 663) |
| Kawasaki | 619 (181) | 605 (339–924) | 630 (604 to 657) |
| Osaka | 672 (214) | 649 (371–1029) | 675 (642 to 710) |
| Kanazawa | 556 (183) | 527 (298–894) | 589 (552 to 628) |
| Nagasaki | 566 (177) | 550 (316–922) | 583 (552 to 615) |
| p Value | p<0.0001 | ||
*Calculated cFT.
Observed: results based on raw data.
Adjusted median and 95% CI calculated by linear regression analysis, adjusted to blood sampling at 10:00 in winter season, representing a 21-year-old man having a BMI of 21.
p Value based on regression analyses of natural logarithmic transformed values, comparing all four groups.
(5–95), 5–95th percentile.
BMI, body mass index; cFT, free testosterone; FSH, follicle-stimulating hormone; LH, luteinising hormone; SHBG, sex hormone-binding globulin.