Table 1

Characteristics of studies included in our preferred meta-analysis

SourceInclusion criteriaExclusion criteriaAntibiotic usedOxford Quality Scale scores
Wax et al8Single fetus ≥37 weeks of gestationPenicillin or cephalosporin allergy, antibiotic use within 2 weeks of delivery, temperature ≥37.8°C, administration of B streptococcal orsubacute bacterial endocarditis prophylaxis, insulin-dependent diabetes mellitus, human immunodeficiency virus infection, chronic glucocorticoid use, multiple gestationCefazolin 1 g2215
Thigpen et al9Acute chorioamnionitis, allergy to penicillin or cephalosporins, caesarean section without labour, systemic antibiotics within past 2 weeksCefazolin 2 g2215
Sullivan et al10>24 weeks gestational ageCephalosporin allergy, age <18 years, antibiotic exposure within 1 week of delivery, emergency caesarean sectionCefazolin 1 g2215
Nokiani et al11Normal healthy women, afebrile, amniotic membrane intact or ruptured for not more than 18 h, first caesarean sectionConfirmed systemic disease (diabetes mellitus, hypertension, immune compromised diseases, coagulation disorders, heart or renal failure)Cefazolin 2 g1102
Witt et al6Gestational age ≥37 weeks, reassuring fetal heart traces; rupture of membranes and labor contractions were allowedFever >38°C, cephalosporin allergy, age <18 years, antibiotic exposure within 1 week before deliveryCefazolin 2 g2215