Health-related quality of life (ERTOC QLQ-C30, European Organisation for Research and Treatment of Cancer QoL Questionnaire; and EQ-5D, EuroQol-5D) outcome variables and estimated differences
| Outcome variable | Mean (SD) | Estimated mean difference (95% CI) | p Value* | ||
|---|---|---|---|---|---|
| Baseline | 12 months | 24 months | |||
| Global health status | |||||
| Surgeon | 70.7 (22.5) | 75.9 (19.2) | 85.0 (16.8) | ||
| GP | 70.4 (20.8) | 81.3 (17.0) | 86.5 (16.2) | −2.23 (−5.7 to 1.2) | 0.20 |
| Physical functioning | |||||
| Surgeon | 80.5 (23.6) | 88.8 (15.0) | 88.0 (17.0) | ||
| GP | 74.5 (24.9) | 90.6 (16.6) | 93.3 (16.0) | −2.4 (−5.7 to 0.8) | 0.14 |
| Role functioning | |||||
| Surgeon | 62.5 (37.3) | 83.8 (26.5) | 90.3 (18.6) | ||
| GP | 62.7 (37.5) | 91.6 (22.1) | 93.7 (20.7) | −5.1 (−9.7 to (−0.5)) | 0.02 |
| Emotional functioning | |||||
| Surgeon | 87.4 (18.1) | 87.7 (16.1) | 87.7 (16.9) | ||
| GP | 85.8 (23.2) | 91.9 (15.8) | 94.4 (17.3) | −3.7 (−6.8 to (−0.6)) | 0.01 |
| Cognitive functioning | |||||
| Surgeon | 87.0 (20.6) | 86.5 (22.8) | 90.3 (15.0) | ||
| GP | 72.4 (31.8) | 91.1 (17.0) | 93.0 (21.3) | −1.7 (−5.0 to 1.4) | 0.27 |
| Social functioning | |||||
| Surgeon | 70.7 (30.5) | 87.0 (23.8) | 90.4 (15.6) | ||
| GP | 72.4 (31.8) | 91.6 (17.3) | 93.0 (21.3) | −4.2 (−8.4 to (−0.009)) | 0.04 |
| Fatigue | |||||
| Surgeon | 32.3 (26.1) | 19.2 (17.1) | 14.6 (23.4) | ||
| GP | 36.9 (28.0) | 22.2 (19.9) | 18.3 (20.8) | 0.24 (−3.7 to 4.2) | 0.9 |
| Nausea and vomiting | |||||
| Surgeon | 6.0 (12.4) | 2.8 (8.5) | 0.9 (3.9) | ||
| GP | 6.5 (14.1) | 3.5 (9.9) | 4.3 (10.3) | −0.8 (−2.8 to 1.2) | 0.4 |
| Pain | |||||
| Surgeon | 22.3 (26.6) | 11.1 (21.9) | 9.6 (16.9) | ||
| GP | 19.1 (28.2) | 9.3 (14.0) | 2.8 (14.7) | 4.5 (0.8 to 8.2) | 0.01 |
| Dyspnoea | |||||
| Surgeon | 18.1 (26.3) | 14.2 (20.2) | 10.5 (19.4) | ||
| GP | 24.0 (32.7) | 12.1 (23.3) | 7.2 (21.2) | 3.0 (−1.2 to 7.2) | 0.1 |
| Insomnia | |||||
| Surgeon | 22.9 (25.4) | 18.5 (25.7) | 17.5 (25.7) | ||
| GP | 28.6 (34.5) | 14.7 (23.4) | 23.6 (25.0) | 2.9 (−1.7 to 7.5) | 0.2 |
| Appetite loss | |||||
| Surgeon | 15.5 (23.1) | 3.7 (10.6) | 1.7 (7.6) | ||
| GP | 20.9 (31.7) | 1.9 (7.9) | 4.1 (11.2) | 0.8 (−2.9 to 3.9) | 0.6 |
| Constipation | |||||
| Surgeon | 27.4 (32.0) | 21.2 (29.9) | 10.5 (19.4) | ||
| GP | 18.6 (33.5) | 7.8 (16.5) | 15.2 (19.6) | 5.1 (0.8 to 9.4) | 0.01 |
| Diarrhoea | |||||
| Surgeon | 24.4 (29.6) | 21.2 (25.3) | 24.5 (24.4) | ||
| GP | 31.0 (33.6) | 22.5 (26.8) | 23.6 (28.6) | −1.0 (−5.7 to 3.5) | 0.6 |
| Financial difficulties | |||||
| Surgeon | 9.8 (26.2) | 9.2 (20.4) | 7.0 (21.0) | ||
| GP | 6.9 (21.2) | 1.9 (7.9) | 4.1 (11.2) | 2.7 (−0.4 to 5.8) | 0.08 |
| EQ-5D Index score | |||||
| Surgeon | 0.83 (0.16) | 0.85 (0.20) | 0.90 (0.14) | ||
| GP | 0.79 (0.22) | 0.87 (0.18) | 0.89 (0.13) | −0.10 (−0.039 to 0.018) | 0.48 |
| EQ-5D VAS score | |||||
| Surgeon | 72.2 (18.9) | 78.2 (16.2) | 82.4 (16.6) | ||
| GP | 67.4 (17.4) | 79.0 (14.6) | 83.5 (14.8) | −1.10 (−3.9 to 1.7) | 0.44 |
*Adjusted general linear model from 1800 follow-up months, ie, 600 quality of life questionnaires (GP 299 vs surgeon 301).
EQ-5D, EuroQol-5D; GP, general practitioner; VAS, visual analogue scale.