TableĀ 1

Summary of design and demographics of studies in the analysis dataset

StudyDrugDose (mg/day)Treatment duration (weeks)Patients (n)Baseline age (years)Female (%)Baseline HbA1c (%)Baseline BMI (kg/m2)Washout duration (weeks)Concomitant medications
Aschner et al30PlaceboNA2424454.348.68.0330.814NA
Sitagliptin1002422953.442.98.0130.314NA
2002423854.953.28.0830.314NA
Bergenstal et al 31Sitagliptin1002616652.048.08.5032.00Metformin
Charbonnel et al 32PlaceboNA2422454.740.58.0331.518Metformin
Sitagliptin1002445354.444.27.9630.918Metformin
Goldstein et al 33PlaceboNA2416553.347.28.6832.514NA
Sitagliptin1002417553.648.08.8731.214NA
Hanefeld et al 34PlaceboNA1210755.936.97.5931.48NA
Sitagliptin251210755.148.67.7131.98NA
501210755.354.57.6031.68NA
501210855.255.97.7932.78NA
100121065644.57.7831.68NA
Hermansen et al 35PlaceboNA2410655.245.38.4330.716Glimepiride
Sitagliptin1002410654.447.28.4231.016Glimepiride
PlaceboNA2411357.747.88.2630.716Glimepiride+metformin
Sitagliptin1002411656.647.48.2731.316Glimepiride+metformin
Iwamoto et al 36PlaceboNA127360.231.57.7424.18NA
Sitagliptin25128059.936.37.4925.08NA
50127260.234.77.5724.58NA
100127058.348.67.5624.28NA
200126860.641.27.6524.48NA
Mohan et al 37PlaceboNA1816950.940.08.7024.98NA
Sitagliptin1001833950.943.08.7025.18NA
Nonaka et al 38PlaceboNA127555.034.07.6925.18NA
Sitagliptin10127555.640.07.5425.28NA
Raz et al 39PlaceboNA1810355.537.38.0532.514NA
Sitagliptin1001819354.546.38.0431.814NA
2001819955.449.58.1432.014NA
Rosenstock et al 40PlaceboNA2417456.946.98.0031.018Pioglitazone
Sitagliptin1002416355.642.18.0532.018Pioglitazone
Scheen et al 5Saxagliptin51833458.852.97.6831.10
Sitagliptin1001834358.149.27.6930.90Metformin
Seck et al 29Sitagliptin10010457656.842.97.6931.20Metformin
Scott et al 41PlaceboNA1212155.337.67.8831.610Metformin
Sitagliptin101212255.150.47.8930.88NA
251212256.2527.8530.58NA
501212055.642.37.8931.48NA
1001212155.147.67.9630.48NA
Scott et al 42PlaceboNA188855.341.07.6830.08NA
Sitagliptin100189155.245.07.7530.30NA
Boehringer Ingelheim Study 1218.543PlaceboNA126359.049.28.2730.90NA
Linagliptin0.5125758.022.88.2431.06NA
2.5125560.052.78.3831.56NA
5125456.042.68.3831.26NA
Forst et al 19PlaceboNA127060.038.68.3732.26NA
Linagliptin1126459.043.88.2432.26Metformin
5126260.046.88.4631.66Metformin
10126662.047.08.3531.76Metformin
Del Prato et al 18PlaceboNA2416355.054.08.0029.26Metformin
Linagliptin52433356.051.48.0029.06NA
Taskinen et al 21PlaceboNA2417557.042.38.0230.16NA
Linagliptin52451357.046.88.0929.86Metformin
Owens et al 20PlaceboNA2426258.053.28.1428.26Metformin
Linagliptin52477858.051.58.1528.40Metformin+SU
Gallwitz et al22Linagliptin55277660.040.77.6930.20Metformin+SU
Araki et al44PlaceboNA128060.028.67.9524.38Metformin
Linagliptin51215960.030.28.0724.64NA
101216061.030.07.9825.04NA
Lewin et al45PlaceboNA188256.039.08.6028.14NA
Linagliptin51815857.052.58.6128.36SU
Patel et al23PlaceboNA187356.057.58.0630.06SU
Linagliptin51814757.064.08.1129.06NA
Rafeiro et al24PlaceboNA124359.051.27.9228.66NA
Linagliptin51243558.042.37.9729.76Metformin
  • BMI, body mass index; HbA1c, glycated haemoglobin; NA, not applicable; SU, sulfonylurea.