Table 3

Adjusted linear regression for annual change in eGFR (n=329)

Annual change (ml/min/1.732)95% CIp Value
Predictor variables
 Years of follow-up (slope in reference pop)−1.93−2.31 to −1.56<0.001
Coefficients for ethnicity interaction (additional decline in ml/min/1.732 per year)
 Additional decline in Black population−0.19−0.68 to 0.300.438
 Additional decline in south Asian population0.08−0.31 to 0.480.676
Time-varying variables
 BP ≤ 130/80 mm  Hg × time in years0.620.27 to 0.98<0.001
 HbA1c ≤ 7.5%×time in years0.03−0.33 to 0.390.883
Constant variables
 Ethnicity (White is reference category)
  Black ethnicity−1.67−4.97 to 1.640.322
  South Asian ethnicity−0.51−3.25 to 2.230.716
 Age0.03−0.06 to 0.130.466
 Gender (female is reference category)−2.64−4.87 to −0.400.021
 SBP target at baseline−2.31−3.89 to −0.730.004
 HbA1c value at baseline−0.66−2.37 to 1.060.454
 Vascular disease ever (PVD, CVD, IHD)−1.44−3.66 to 0.790.206
 Drug treatment ever (ACE, ARB, dual block)0.02−4.46 to 4.500.993
 Proteinuria at baseline (PCR>15)0.173−1.99 to 2.330.875
 Baseline eGFR1.050.99 to 1.11<0.001
 Constant−3.18−11.26 to 4.890.440
  • The annual decline in the reference population (White) is −1.93 ml/min.

  • The annual decline in Black patients is −2.12 ml/min.

  • The annual decline in south Asian patients is −1.85 ml/min.

  • ARB, angiotensin receptor blocker; BP, blood pressure; CVD, cerebrovascular disease; eGFR, estimated glomerular filtration rate; HbA1c, glycated haemoglobin; IHD, ischaemic heart disease; PCR, protein creatine ratio; PVD, peripheral vascular disease; SBP, systolic blood pressure