Disease-free colorectal cancer survival in relation to quartiles of dietary patterns by selected lifestyle and tumour characteristics
| Quartiles HR (95% CI)† | |||||||
|---|---|---|---|---|---|---|---|
| Number of events*/no at risk | Q1 | Q2† | Q3 | Q4 | p Value for trend ‡ | p Value for interaction§ | |
| Processed meat pattern | |||||||
| Sex | |||||||
| Female | 65/210 | 1.00 | 2.20 (0.99 to 4.91) | 2.38 (0.97 to 5.85) | 3.85 (1.49 to 9.99) | 0.03 | |
| Male | 133/318 | 1.00 | 1.20 (0.66 to 2.18) | 1.23 (0.69 to 2.17) | 1.22 (0.64 to 2.32) | 0.27 | 0.04 |
| Physical activity | |||||||
| <24.9 MET h/week | 97/263 | 1.00 | 1.96 (1.05 to 3.67) | 2.13 (1.11 to 4.11) | 2.03 (0.96–4.30) | 0.42 | |
| ≥24.9 MET h/week | 101/264 | 1.00 | 1.22 (0.59–2.55) | 1.27 (0.62–2.62) | 1.64 (0.74–3.62) | 0.01 | 0.64 |
| BRAF mutation status | |||||||
| Wild type | 163/425 | 1.00 | 1.28 (0.77 to 2.12) | 1.41 (0.80 to 2.34) | 1.80 (1.01 to 3.21) | 0.009 | |
| V600E mutant | 17/49 | 1.00 | 1.82 (0.40 to 8.34) | 0.54 (0.10 to 2.83) | 0.79 (0.09 to 7.01) | 0.50 | 0.80 |
| Prudent vegetables pattern | |||||||
| Sex | |||||||
| Female | 65/210 | 1.00 | 1.57 (0.59 to 4.20) | 1.55 (0.63 to 3.85) | 1.22 (0.46 to 3.24) | 0.71 | |
| Male | 133/318 | 1.00 | 1.25 (0.76 to 2.04) | 1.08 (0.62 to 1.88) | 1.14 (0.62 to 2.09) | 0.67 | 0.65 |
| Physical activity | |||||||
| <24.9 MET h/week | 97/263 | 1.00 | 1.48 (0.80 to 2.76) | 1.52 (0.81 to 2.87) | 1.22 (0.56 to 2.69) | 0.66 | |
| ≥24.9 MET h/week | 101/264 | 1.00 | 1.02 (0.55 to 1.89) | 1.02 (0.53 to 1.96) | 1.05 (0.55 to 2.04) | 0.03 | 0.83 |
| BRAF mutation status | |||||||
| Wild type | 163/425 | 1.00 | 1.32 (0.83 to 2.10) | 1.29 (0.80 to 2.08) | 1.19 (0.70 to 2.02) | 0.58 | |
| V600E mutant | 17/49 | 1.00 | 2.50 (0.38 to 16.59) | 0.88 (0.06 to 12.99) | 1.24 (0.12 to 13.20) | 0.73 | 0.80 |
| High-sugar pattern | |||||||
| Sex | |||||||
| Female | 65/210 | 1.00 | 1.41 (0.63 to 3.16) | 0.88 (0.36 to 2.15) | 0.82 (0.30 to 2.27) | 0.42 | |
| Male | 133/318 | 1.00 | 1.14 (0.67 to 1.97) | 1.34 (0.75 to 2.39) | 1.39 (0.73 to 2.66) | 0.06 | 0.72 |
| Physical activity | |||||||
| <24.9 MET h/week | 97/263 | 1.00 | 1.01 (0.55 to 1.86) | 1.10 (0.56 to 2.16) | 1.19 (0.56 to 2.54) | 0.06 | |
| ≥24.9 MET h/week | 101/264 | 1.00 | 1.36 (0.70 to 2.65) | 1.21 (0.60 to 2.45) | 1.04 (0.49 to 2.22) | 0.86 | 0.26 |
| BRAF mutation status | |||||||
| Wild type | 163/425 | 1.00 | 0.99 (0.61 to 1.59) | 1.20 (0.71 to 2.01) | 1.03 (0.59 to 1.82) | 0.70 | |
| V600E mutant | 17/49 | 1.00 | 0.53 (0.07 to 4.25) | 0.27 (0.04 to 1.66) | 0.32 (0.04 to 2.64) | 0.09 | 0.33 |
*Events are defined as death/recurrence/metastasis (which occurred earliest) for disease-free survival and deaths for overall survival.
†Cox proportional hazard model adjusted for total energy intake, sex, age at diagnosis, stage at diagnosis, body mass index, marital status, family history, reported screening procedure, reported chemoradiotherapy and MSI status, where appropriate.
‡Two-sided p Value for test of linear trend was calculated by modelling median values for each quartile of dietary pattern scores as an ordinal variable.
§p Value for interaction is the significance of interaction term between smoking and respective stratification variable, calculated from Wald test.
HR, hazard rate ratio; METh/week, metabolic equivalent hours per week.