Reproductive hormone levels of fertile men from four cities in Japan
| Observed | Adjusted | ||
|---|---|---|---|
| Mean (SD) | Median (5–95) | Median (95% CI) | |
| FSH (U/l) | |||
| Entire study population | 4.1 (2.4) | 3.6 (1.8–7.8) | 3.9 (3.6 to 4.2) |
| Sapporo | 4.3 (2.4) | 3.7 (1.7–8.6) | 4.2 (3.8 to 4.6) |
| Osaka | 4.1 (2.8) | 3.7 (1.8–7.7) | 3.8 (3.5 to 4.2) |
| Kanazawa | 4.1 (2.1) | 3.5 (1.8–7.7) | 4.0 (3.7 to 4.4) |
| Fukuoka | 4.0 (2.0) | 3.6 (2.0–7.0) | 3.7 (3.4 to 4.1) |
| p Value | 0.2 | ||
| Inhibin-B (pg/ml) | |||
| Entire study population | 178 (56) | 173 (94–279) | 176 (167 to 186) |
| Sapporo | 182 (56) | 179 (104–278) | 179 (167 to 194) |
| Osaka | 190 (59) | 187.5 (104–297) | 188 (176 to 201) |
| Kanazawa | 161 (52) | 162 (83–260) | 158 (147 to 170) |
| Fukuoka | 180 (50) | 169 (117–279) | 178 (165 to 192) |
| p Value | <0.0001 | ||
| LH (U/l) | |||
| Entire study population | 3.7 (1.5) | 3.5 (1.9–6.4) | 3.3 (3.1 to 3.5) |
| Sapporo | 3.8 (1.6) | 3.4 (1.9–6.3) | 3.5 (3.2 to 3.8) |
| Osaka | 3.5 (1.4) | 3.3 (1.8–5.6) | 3.2 (3.0 to 3.5) |
| Kanazawa | 4.0 (1.6) | 3.8 (2–7.1) | 3.7 (3.4 to 4.0) |
| Fukuoka | 3.4 (1.4) | 3.2 (1.7–6.1) | 3.1 (2.9 to 3.4) |
| p Value | 0.0002 | ||
| Testosterone (nmol/l) | |||
| Entire study population | 20 (7) | 18 (11–31) | 19 (18 to 20) |
| Sapporo | 19 (6) | 18 (10–31) | 18 (17 to 20) |
| Osaka | 19 (6) | 18 (12–28) | 19 (18 to 20) |
| Kanazawa | 22 (7) | 21 (12–33) | 21 (20 to 23) |
| Fukuoka | 19 (8) | 17 (10–30) | 18 (17 to 19) |
| p Value | <0.0001 | ||
| SHBG (nmol/l) | |||
| Entire study population | 33 (15) | 31 (16–56) | 31 (30 to 33) |
| Sapporo | 34 (14) | 33 (16–58) | 34 (31 to 36) |
| Osaka | 33 (15) | 31 (17–56) | 33 (30 to 35) |
| Kanazawa | 34 (15) | 31 (16–56) | 33 (30 to 35) |
| Fukuoka | 30 (15) | 27 (15–52) | 29 (27 to 31) |
| p Value | 0.02 | ||
| cFT (pmol/l) | |||
| Entire study population | 416 (143) | 392 (251–642) | 400 (382 to 419) |
| Sapporo | 384 (113) | 363 (238–625) | 376 (354 to 399) |
| Osaka | 400 (123) | 381 (255–591 | 399 (377 to 421 |
| Kanazawa | 464 (154) | 440 (268–677) | 448 (422 to 476) |
| Fukuoka | 410 (183) | 392 (240–614 | 395 (372 to 420) |
| p Value | <0.0001 | ||
Observed: results based on raw data.
Adjusted median and 95% CI calculated by linear regression analysis, adjusted to blood sampling at 10:00 h in winter season, representing of 32-year-old man having a BMI of 23.
p Value based on regression analyses of natural logarithmic transformed values comparing all four groups.
(5–95): 5–95th percentile; BMI, body mass index; cFT, calculated free-testosterone; FSH, follicle-stimulating hormone; LH, luteinising hormone; SHBG, sex hormone-binding globulin.