Resting echocardiographic parameters stratified by diastolic function
| Echocardiographic parameters | Normal diastolic function (N=102) | Stage 1 DD (N=243) | Stage ≥ 2DD (N=150) | p Value |
|---|---|---|---|---|
| LVIDD/height, mean (SD) (cm/m) | 2.3 (0.3) | 2.4 (0.4) | 2.4 (0.4) | 0.27 |
| LVIDS/height, mean (SD) (cm/m) | 1.3 (0.3) | 1.4 (0.3) | 1.4 (0.3) | 0.53 |
| LVEF, mean (SD) (%) | 61 (5) | 62 (5) | 60 (5) | 0.091 |
| IVS, mean (SD) (cm) | 2.1 (0.5) | 2.0 (0.5) | 2.2 (0.6) | 0.081 |
| PWT mean (SD) (cm) | 1.3 (0.3) | 1.3 (0.3) | 1.4 (0.3) | 0.053 |
| LV mass, mean (SD) (g) | 287 (91) | 289 (103) | 316 (112) | 0.036 |
| LV mass index, mean (SD) (g/m2.7) | 63 (19) | 68 (24) | 73 (23) | 0.003 |
| RVSP, mean (SD) (mm Hg) | 28 (8) | 30 (8) | 35 (10) | <0.0001 |
| LA size, mean (SD) (cm) | 4.3 (0.7) | 4.3 (0.7) | 4.6 (0.8) | 0.012 |
| LA area, mean (SD) (cm2) | 21 (6) | 24 (8) | 25 (8) | 0.002 |
| LAVI, mean (SD) (ml/m2) | 32 (12) | 43 (21) | 45 (21) | <0.0001 |
| LVOT rest gradient, mean (SD) (mm Hg) | 35 (37) | 42 (40) | 40 (39) | 0.40 |
| LVOT gradient postamyl nitrate, mean (SD) (mm Hg) | 69 (42) | 79 (45) | 65 (41) | 0.068 |
| Resting SAM* | 0.59 | |||
| Mild | 93 (91%) | 48 (86%) | 134 (89%) | |
| Moderate | 4 (4%) | 17 (7%) | 6 (4%) | |
| Severe | 5 (5%) | 17 (7%) | 10 (7%) | |
| Mitral regurgitation | 0.077 | |||
| None or mild | 65 (64%) | 136 (56%) | 74 (49%) | |
| Moderate | 37 (36%) | 107 (44%) | 76 (51%) |
*None or mild SAM was defined as systolic anterior movement of the mitral valve with >1 cm separation from the interventricular septum; moderate SAM if the separation was 0.5–1.0 cm; and severe SAM if the separation was <0.5 cm or there was septal contact.
DD, diastolic function; IVS, interventricular septum; LA, left atrium; LAVI, left atrial volume index; LV, left ventricle; LVEF, left ventricular ejection fraction; LVIDD, left ventricular internal diameter, end-diastole; LVIDS, left ventricular internal diameter, end-systole; LVOT, left ventricular outflow tract; PWT, posterior wall thickness; RVSP, right ventricular systolic pressure; SAM, systolic anterior motion of the mitral valve.