Table 2

Number of patients in each COD category and the MS relationship for the 81 deaths in the different randomised treatment-allocation groups (numbers in parentheses represent MS-related deaths)

IFNβ-1b
Placebo50 µg250 µgTotal
Number of Deaths37222281
Category of death
1. Cardiovascular disease and stroke4 (1)1 (0)5 (1)10 (2)
2. All cancers1 (0)3 (0)2 (1)6 (1)
3. Pulmonary infectious diseases12 (11)2 (2)3 (3)17 (16)
4. Sepsis*0000
5. Accidental death2 (1)0 (0)1 (1)3 (2)
6. Suicide3 (3)2 (2)3 (3)8 (8)
7. Death due to MS9 (9)6 (6)6 (6)21 (21)
8. Other known COD1 (0)1 (1)0 (0)2 (1)
Total: COD known32 (25)15 (11)20 (15)67 (51)
Other MS relationships
COD known; MS relation unknown1012
MS relation known; COD unknown1 (1)2 (1)1 (1)4 (3)
COD unknown; MS relation unknown45110
Total: MS relationship known32172069
  • *NB: The NDI death-certificate data does not include ‘sepsis’ as a separate COD  category. Therefore these entries are all zero.

  • COD, cause-of-death; IFNβ-1b, interferon β-1b; MS, multiple sclerosis.