Decision algorithm for determining the relationship of death to MS
| Always MS related | Probably MS related | Probably not MS related |
|---|---|---|
| 1. Suicide | 1. Brainstem dysfunction | 1. CV disease and stroke |
| 2. EDSS ≥7.0 prior to death | 2. Pulmonary infections | 2. All cancers |
| 3. MS the only listed COD | 3. Aspiration pneumonia | 3. Other infections |
| 4. Death due to MS | 4. Respiratory insufficiency | 4. Single organ failure |
| 5. Death from MS treatment | 5. Pulmonary embolism | |
| 6. Sepsis (especially uro-sepsis) | ||
| 7. Death due to trauma |
COD, cause-of-death; CV, cardiovascular; EDSS, Extended Disability Status Scale; MS, multiple sclerosis.