Table 1

Decision algorithm for determining the relationship of death to MS

Always MS relatedProbably MS relatedProbably not MS related
1. Suicide1. Brainstem dysfunction1. CV disease and stroke
2. EDSS ≥7.0 prior to death2. Pulmonary infections2. All cancers
3. MS the only listed COD3. Aspiration pneumonia3. Other infections
4. Death due to MS4. Respiratory insufficiency4. Single organ failure
5. Death from MS treatment5. Pulmonary embolism
6. Sepsis (especially uro-sepsis)
7. Death due to trauma
  • COD, cause-of-death; CV, cardiovascular; EDSS, Extended Disability Status Scale; MS, multiple sclerosis.