Therapeutic area | Prepolicy trend | Immediate change after policy | Postpolicy trend change |
---|---|---|---|
Diabetes | |||
Antidiabetics† | ↑ | ↑ | |
Insulins† | ↑ | ↑ | ↑ |
Cardiovascular disease | |||
Antihypertensives | ↑ | ↓ | ↑ |
Lipid-regulating agents† | ↑ | ↑ | |
Cardiac therapy | ↑ | ↓ | |
Cancer | |||
Antineoplastics | ↑ | ||
Cytostatic hormones | ↑ | ↑ | |
Immunostimulating agents† | ↑ | ↓ |
*Arrows signify a statistically significant coefficient (p<0.05) from segmented regression with linear postpolicy trend term, unless noted otherwise.
†Quadratic model (which has a squared postpolicy trend term) fits better than linear model.
Note: See online appendix table 2 and figures 1–8 for regression coefficients and figures for all therapeutic areas.