Table 4

Comparison of agreement with statements about specific diagnostic criteria for FAS between paediatricians and other health professionals

Round 1% agreement (IQD)
StatementnPaediatricianOtherStatement
Facial anomalies
 1. All three of the following characteristic FAS facial anomalies: (short-palpebral fissures, thin-upper lip and smooth philtrum)5471.4 (3)76.9 (1)0.65
 2. Two or more of the following characteristic FAS facial anomalies: (short-palpebral fissures, thin-upper lip and smooth philtrum)5250.0 (2)62.5 (2)0.37
 3. Evidence of a characteristic pattern of FAS facial anomalies that includes features such as short-palpebral fissures and abnormalities in the premaxillary zone (eg, flat-upper lip and flattened philtrum)5444.8 (2)68.0 (2)0.09
Growth deficit
 4. Prenatal or postnatal growth deficit in height or weight at or below the 10th percentile5072.4 (1)90.5 (1)0.16
 5. Disproportionately low weight-to-height ratio at or below 10th percentile4548.1 (1)66.7 (1)0.22
 6. Disproportional low weight to height4642.9 (2)61.1 (2)0.23
 7. Low-birth weight for gestational age5053.3 (1)60.0 (1)0.64
 8. Decelerating weight over time not due to nutrition4942.9 (2)66.7 (2)0.10
CNS abnormalities—general
 9. At least one structural CNS abnormality (including decreased cranial size),4560.0 (1)50.0 (2)0.50
10. At least one of the following CNS abnormalities: structural (abnormal-brain structure, including decreased cranial size) or neurological (hard or soft neurological signs)4937.0 (2)54.5 (1)0.22
11. At least one of the following CNS abnormalities:
structural (abnormal-brain structure, including decreased cranial size) or neurological (hard or soft neurological signs) or functional (global cognitive or intellectual deficits representing multiple domains of deficit (including significant developmental delay in young children) or deficits in three or more specific functional domains (eg, developmental milestones, cognition, memory, executive functioning, attention, hyperactivity, social, communication and language, motor and sensory))
4976.9 (1)73.9 (1)0.81
12. Three or more of the following CNS abnormalities: structural (abnormal-brain structure, including decreased cranial size), neurological (hard or soft neurological signs), cognition, communication, academic achievement, memory, executive functioning and abstract reasoning, attention deficit or hyperactivity, adaptive behaviour, social skills and social communication5042.9 (2)81.8 (1)0.004
CNS abnormalities—specific
13. Decreased-cranial size at or below the third percentile5090.9 (1)82.4 (1)0.40
14. Decreased-cranial size at or below the 10th percentile4725.8 (2)43.8 (2)0.22
15. Global-functional performance (cognitive or intellectual) below the third percentile5278.8 (1)78.9 (1)1.00
16. Performance for specific-functional domains below the third percentile5077.4 (0)89.5 (1)0.45
17. Performance for specific-functional domains below the 16th percentile4617.9 (1)44.4 (2)0.052
18. Clinical judgement of functional impairment or deficit in domains where standardised measurements are not available5362.5 (1)52.4 (2)0.47
19. Clinical judgement of functional impairment or deficit based on clinical assessment5642.4 (2)47.8 (2)0.69
  • *χ test for independence by occupation (paediatrician vs other occupation).

  • Statements that reached 70% agreement (‘agree’ or ‘strongly agree') for the total sample are presented in italic.

  • CNS, central nervous system; FAS, fetal alcohol syndrome; IQD, interquartile deviation