Table 1

Data from reports providing the number of patients from which the study population was derived

PublicationHistologyStart dateEnd dateAll registered sarcoma patients (A)Patients with pulmonary metastases (B)Pulmonary metastasectomy as reported in cited papers in systematic review (C)Proportion of sarcoma patients with pulmonary metastases (=B/A) (%)Proportion of patients with pulmonary metastases who have metastasectomy (data as in reports) (=C/B) (%)Proportion of all sarcoma patients who have pulmonary metastectomy (=C/A) (%)
Antunes 1999Bone19891997198*3116
Harting 2006Bone19802000272†137‡99507236
Briccoli 2010Bone198520051197§369¶323318827
Buddingh 2009Bone19902008197**88††56456428
Gadd 1993STS19831990716‡‡135§§78195811
Rehders 2007STS19912002678¶¶121***6118509
Blackmon 2009Mixed1998200615744†††4355‡‡‡2342851
  • *Patients operated on for osteogenic sarcomas of the limbs were followed in their centre.

  • †Patients with osteosarcoma of the trunk or extremities who were younger than 21 years and who had medical records available for review.

  • ‡Developed or presented with radiographically evident pulmonary nodules. These 137 patients formed the initial study cohort.

  • §Patients with histologically proven HGOS of the extremity 55 years old or younger diagnosed at their Institution.

  • ¶First recurrence with metastases located only in the lung.

  • **Patients under the age of 40 treated for high-grade OS at the Leiden University Medical Center.

  • ††Patients who had pulmonary metastases either at diagnosis or during follow-up.

  • ‡‡Adult patients with a primary or locally recurrent extremity soft tissue sarcoma admitted to MSKCC.

  • §§iPatients with pulmonary metastases.

  • ¶¶Patients with STS were treated at the Department of Surgery, University Hospital.

  • ***Pulmonary metastasis of STS occurred during follow-up.

  • †††Patients with soft tissue and bone sarcoma referred to The University of Texas M.D. Anderson Cancer Center.

  • ‡‡‡Patients diagnosed with sarcomatous pulmonary metastases.

  • HGOS, high grade osteosarcoma; MSKCC, Memorial Sloan-Kettering Cancer Centre; OS, osteosarcoma; STS, soft tissue sarcoma.