Table 4

Selected clinical and laboratory characteristics of individual collaborating cohorts and the combined cohort

VariableCohort 1 (n=1847)Cohort 2 (n=2110)Cohort 3 (n=2287)Cohort 4 (n=3415)Cohort 5 (n=1014)Cohort 6 (n=3201)ICCC (n=13 874)
Confusion
 Yes57 (3.1)269 (12.7)238 (10.4)701 (20.5)92 (9.1)121 (3.8)1478 (10.7)
 No1689 (91.4)1841 (87.3)2047 (89.5)2714 (79.5)922 (90.9)3080 (96.2)12 293 (88.6)
 Missing101 (5.5)0 (0)2 (<0.1)0 (0)0 (0)0 (0)103 (0.7)
BUN
 Continuous28 (12–43) (n=2110)23 (5–41) (n=1500)26 (5–47) (n=2930)23 (7–39) (n=1014)21 (7–36) (n=2518)
 Categorical
  ≥30 (mg/dl)264 (14.3)660 (31.3)326 (14.3)748 (21.8)198 (19.5)430 (13.4)2626 (18.8)
  <30 (mg/dl)1456 (78.8)1450 (68.7)1174 (51.3)2185 (64.1)816 (80.5)2088 (65.2)9169 (66.1)
  Missing127 (6.9)0 (0)787 (34.4)482 (14.1)0 (0)683 (21.3)2079 (15.0)
 Urea (mmol/l)9.9 (4.4–15.5) (n=2110)8.2 (1.8–14.6) (n=1500)9.3 (1.9–16.7) (n=2930)8.3 (2.4–14.1) (n=1014)7.7 (2.4–12.8) (n=2518)
Respiratory rate/min
 Continuous23 (16–30) (n=2110)24 (15–33) (n=1805)26 (18–34) (n=3294)24 (19–30) (n=1014)23 (17–28) (n=3201)
 Respiratory rate high24 (20–28)
 Respiratory rate low20 (18–20)
 Categorical
  >30 (/min)0 ()275 (13.0)269 (11.8)787 (23.1)125 (12.3)287 (9.0)1743 (12.6)
  ≤30 (/min)0 (0)1835 (87.0)1525 (67.0)2504 (73.4)889 (87.7)2896 (90.5)9649 (69.6)
  Missing/NA1847 (100)0 (0)482 (21.2)121 (3.5)0 (0)18 (0.6)2468 (17.8)
Systolic BP (mm Hg)
 Continuous132 (27) (n=2106)134 (28) (n=2020)134 (27) (n=3371)145 (28) (n=1014)138 (26) (n=3192)– (n=13 874)
 Categorical
  ≥90 mm Hg1650 (89.3)1999 (94.9)1971 (86.2)3282 (96.2)1002 (98.8)3140 (98.1)13 044 (94.1)
  <90 mm Hg68 (3.7)107 (5.1)49 (2.1)89 (2.6)12 (1.2)52 (1.6)377 (2.7)
  Missing129 (7.0)0 (0)267 (11.7)41 (1.2)0 (0)9 (0.3)446 (3.2)
Diastolic BP (mm Hg)72 (15) (n=2074)76 (15) (n=1936)75 (16) (n=3365)73 (16) (n=1014)75 (15) (n=3156)
 Diastolic BP high77 (62–92)
 Diastolic BP low63 (49–79)
Temperature (°C)37.5 (1.0) (n=2110)37.6 (1.1) (n=2018)37.3 (1.2) (n=3369)37.9 (1.1) (n=1014)37.6 (1.1) (n=3168)
Heart rate (beats per minute)98 (21) (n=2110)99 (20) (n=1971)101 (22) (n=3401)102 (20) (n=1014)99 (20) (n=3197)
 Heart rate high104 (84–125)
 Heart rate low85 (68–102)
PaO2 (mm Hg)61 (47–75) (n=2050)70 (41–100) (n=959)68 (37–100) (n=2278)93 (64–122) (n=1013)74 (37–112) (n=593)
pH7.45 (7.38–751) (n=2052)7.45 (7.37–7.51) (n=959)7.43 (7.33–7.50) (n=2248)7.41 (7.32–7.49) (n=1014)7.42 (7.35–7.49) (n=593)
Glucose (mg/dl)151 (81–220) (n=2108)141 (72–209) (n=1459)142 (76–209) (n=2987)137 (84–191) (n=1014)123 (74–214) (n=2510)
 Glucose high147 (67–227)
 Glucose low135 (75–196)
Sodium (mmol/l)136 (131–141) (n=2110)137 (132–142) (n=1495)137 (132–143) (n=3272)136 (131–140) (n=1013)137 (133–141) (n=2524)
 Sodium high137 (132–142)
 Sodium low137 (132–142)
  • Values presented are mean (SD) for normally distributed (systolic BP, diastolic BP, temperature and heart rate) and median (IQR) for non-normally distributed continuous data (other continuous variables) and number (%) for all categorical data. Percentages may not sum to 100% due to rounding.

  • BP, blood pressure; BUN, blood urea nitrogen; ICCC, International Community-Acquired Pneumonia (CAP) Collaboration Cohort; NA, not available.