Association between birth weight or postnatal growth and non-optimal neurodevelopment
| EPIPAGE cohort | LIFT cohort | |||
| OR (95% CI) | p Value | OR (95% CI) | p Value | |
| Birth weight (per one Z-score unit below the mean) | n=1460 | n=1463 | ||
| No adjustment | 1.19 (1.04 to 1.35) | 0.01 | 1.12 (0.99 to 1.28) | 0.08 |
| Adjusted for gestational age, sex | 1.23 (1.07 to 1.40) | 0.003 | 1.24 (1.08 to 1.43) | 0.001 |
| Postnatal growth for weight (per one Z-score unit lost between birth and discharge) | n=1430 | n=1463 | ||
| No adjustment | 0.93 (0.78 to 1.11) | 0.44 | 1.29 (1.10 to 1.51) | 0.002 |
| Adjusted for gestational age, sex, birthweight Z-score | 0.97 (0.79 to 1.19) | 0.74 | 1.21 (1.01 to 1.44) | 0.038 |
| Adjusted for gestational age, sex, birthweight Z-score, breast feeding and propensity score* | 1.06 (0.85 to 1.31) | 0.63 | 1.28 (1.07 to 1.53) | 0.008 |
Non-optimal neurodevelopment was defined as Kaufman Assessment Battery for Children Mental Composite Processing <85 at 5 years in EPIPAGE cohort and Age and Stages Questionnaires score <220 at 2 years of corrected age in LIFT cohort.
↵* n=1417.
LIFT, Loire Infant Follow-up Team.