Table 3

Health-related quality of life (EORTC QLQ-C30) outcome variables and mean differences at 6 and 4 months (95% CI)

Outcome variable6 months14 months
nMean (CI)Mean difference (95% CI)p ValuenMean (CI)Mean difference (95% CI)p Value
Global health status/quality of life
 Control group29768.0 (65.5 to 70.5)24672.8 (70.3 to 75.3)
 Intervention group28169.3 (66.7 to 71.9)1.25 (−2.4 to 4.9)0.5024072.1 (69.6 to 74.7)−0.71 (−4.3 to 2.8)0.69
Physical functioning
 Control group29479.0 (76.4 to 81.5)24081.9 (79.3 to 84.5)
 Intervention group28079.7 (77.1 to 82.4)0.77 (−2.9 to 4.4)0.6823482.0 (79.4 to 84.6)−0.08 (−3.6 to 3.8)0.97
Role functioning
 Control group29171.3 (67.7 to 74.9)23978.0 (74.4 to 81.7)
 Intervention group27772.5 (68.8 to 76.1)1.18 (−3.9 to 6.3)0.6523578.8 (75.0 to 82.5)0.70 (−4.5 to 5.9)0.79
Emotional functioning
 Control group29380.5 (78.1 to 83.0)24080.7 (77.9 to 83.4)
 Intervention group27881.6 (79.1 to 84.1)1.02 (−2.5 to 4.5)0.5723880.8 (78.0 to 83.6)0.12 (−3.8 to 4.1)0.95
Cognitive functioning
 Control group29083.0 (80.5 to 85.5)24582.6 (79.7 to 85.5)
 Intervention group27883.9 (81.3 to 86.4)0.88 (−2.7 to 4.5)0.6323885.1 (82.1 to 88.2)2.53 (−1.7 to 6.7)0.24
Social functioning
 Control group29585.7 (83.0 to 88.4)24288.2 (85.4 to 91.0)
 Intervention group28086.0 (83.2 to 88.8)0.28 (−3.6 to 4.2)0.8923887.4 (84.6 to 90.3)−0.77 (−4.8 to 3.2)0.71
Fatigue
 Control group29237.4 (34.3 to 40.6)24432.1 (28.8 to 35.3)
 Intervention group27934.2 (30.9 to 37.4)−3.27 (−7.8 to 1.3)0.1623432.3 (28.9 to 35.6)0.23 (−4.5 to 4.9)0.92
Nausea and vomiting
 Control group3008.1 (6.1 to 10.0)2445.5 (3.9 to 7.2)
 Intervention group2848.0 (6.0 to 10.0)−0.11 (−2.9 to 2.7)0.942365.6 (3.9 to 7.3)0.05 (−2.3 to 2.4)0.97
Pain
 Control group28323.0 (19.8 to 20.2)24121.9 (18.5 to 25.4)
 Intervention group27422.0 (18.8 to 25.3)−0.95 (−5.5 to 3.6)0.6823421.4 (17.8 to 24.9)−0.56 (−5.5 to 4.4)0.83
Dyspnoea
 Control group29717.0 (13.9 to 20.2)24513.2 (10.0 to 16.5)
 Intervention group28617.9 (14.7 to 21.2)0.87 (−3.6 to 5.4)0.7123315.4 (11.9 to 18.8)2.11 (−2.6 to 6.8)0.38
Insomnia
 Control group30227.5 (24.0 to 31.0)24829.6 (25.6 to 33.6)
 Intervention group28527.3 (23.6 to 30.9)−0.23 (−5.3 to 4.8)0.9324028.5 (24.4 to 32.6)−1.08 (−6.8 to 4.6)0.71
Appetite loss
 Control group30114.1 (11.0 to 17.2)2469.6 (7.1 to 12.2)
 Intervention group28815.9 (12.7 to 19.0)1.79 (−2.7 to 6.2)0.432397.9 (5.4 to 10.5)−1.67 (−5.3 to 2.0)0.37
Constipation
 Control group29912.6 (9.7 to 15.5)24811.9 (9.0 to 14.91)
 Intervention group28411.3 (8.3 to 14.2)−1.33 (−5.4 to 2.8)0.532368.9 (5.9 to 11.9)−3.03 (−5.5 to 2.8)0.16
Diarrhoea
 Control group29911.3 (8.8 to 13.9)25011.4 (8.5 to 14.2)
 Intervention group28411.4 (8.8 to 14.1)0.08 (−3.6 to 3.8)0.9723810.0 (7.0 to 13.0)−1.38 (−5.5 to 2.8)0.51
Financial difficulties
 Control group2977.6 (5.4 to 9.8)2426.5 (3.9 to 9.0)
 Intervention group2848.0 (5.7 to 10.2)0.34 (−2.8 to 3.5)0.832366.7 (4.1 to 9.4)0.27 (−3.4 to 4.0)0.89
  • Mean values from 0 to 100. A score of 100 indicates optimal function or maximum symptom intensity (ie, for functional measures, an increase indicates improvement, while for symptoms, an increase indicates worsening).

  • EORTC QLQ-C30, European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30.