Table 1

Antidepressant affinity groups by affinity for serotonin transporter*

Affinity groupAntidepressantInhibition constant (Ki) (mean±SD)
HighParoxetine0.065±0.006
Duloxetine(0.07±0.01)
Sertraline0.29±0.01
Escitalopram(0.79±0.13)
Fluoxetine0.9±0.06
ModerateCitalopram1.5±0.03
Fluvoxamine1.6±0.1
Venlafaxine7.5±0.4
LowNefazodone459±28
Bupropion§
Mirtazapine§
  • * Adapted from Owens et al.42

  • Ki drawn from Vaishnavi et al37; relative order confirmed in Martin et al.36 (J Pharmacol Exp Ther).

  • Ki drawn from Apparsundaram et al35; relative order confirmed in Martin et al.36 (J Pharmacol Exp Ther).

  • § Not reported; Tatsumi et al.44 reports KD=9100 for bupropion and KD>10 000 for mirtazapine (vs 200 for nefazodone).