Antidepressant affinity groups by affinity for serotonin transporter*
| Affinity group | Antidepressant | Inhibition constant (Ki) (mean±SD) |
| High | Paroxetine | 0.065±0.006 |
| Duloxetine | (0.07±0.01)† | |
| Sertraline | 0.29±0.01 | |
| Escitalopram | (0.79±0.13)‡ | |
| Fluoxetine | 0.9±0.06 | |
| Moderate | Citalopram | 1.5±0.03 |
| Fluvoxamine | 1.6±0.1 | |
| Venlafaxine | 7.5±0.4 | |
| Low | Nefazodone | 459±28 |
| Bupropion | § | |
| Mirtazapine | § |
↵* Adapted from Owens et al.42
↵† Ki drawn from Vaishnavi et al37; relative order confirmed in Martin et al.36 (J Pharmacol Exp Ther).
↵‡ Ki drawn from Apparsundaram et al35; relative order confirmed in Martin et al.36 (J Pharmacol Exp Ther).
↵§ Not reported; Tatsumi et al.44 reports KD=9100 for bupropion and KD>10 000 for mirtazapine (vs 200 for nefazodone).