Table 3

Age- and multivariable-adjusted HRs for incident vascular events according to RLS status in the WHS

Primary analysis (n=29 756)Sensitivity analysis* (n=27 649)
No RLS history (n=26 269)Any history of RLS (n=3487)No RLS history (n=24 472)Any history of RLS (n=3177)
HR (95% CI)HR (95% CI)
Major cardiovascular eventn=386n=64n=338n=56
 Age adjusted1.001.25 (0.96 to 1.63)1.001.27 (0.96 to 1.69)
 Multivariable adjusted1.001.15 (0.88 to 1.50)1.001.18 (0.89 to 1.57)
Any stroken=207n=38n=178n=35
 Age adjusted1.001.39 (0.98 to 1.96)1.001.51 (1.05 to 2.16)
 Multivariable adjusted1.001.29 (0.91 to 1.82)1.001.42 (0.99 to 2.05)
Myocardial infarctionn=153n=23n=138n=20
 Age adjusted1.001.13 (0.73 to 1.75)1.001.11 (0.69 to 1.77)
 Multivariable adjusted1.001.01 (0.65 to 1.57)1.001.00 (0.62 to 1.59)
Coronary revascularisationn=388n=73n=346n=59
 Age adjusted1.001.42 (1.10 to 1.82)1.001.30 (0.99 to 1.72)
 Multivariable adjusted1.001.24 (0.96 to 1.59)1.001.14 (0.86 to 1.50)
CVD deathn=57n=9n=52n=6
 Age adjusted1.001.21 (0.60 to 2.45)1.000.90 (0.39 to 2.09)
 Multivariable adjusted1.001.11 (0.55 to 2.25)1.000.85 (0.36 to 1.98)
  • * 2107 women with polyneuropathy, liver disease, kidney disease/failure, peripheral artery disease surgery, intermittent claudication and rheumatoid arthritis were excluded from the analysis.

  • Adjusted for age, randomised treatment assignments, history of hypertension, history of diabetes, history of hypercholesterolaemia, parental history of myocardial infarction, history of migraine, alcohol consumption, body mass index, smoking, exercise and postmenopausal hormone use.

  • CVD, cardiovascular disease; RLS, restless legs syndrome; WHS, Women's Health Study.