Predictive performance of individual serum miRNAs and miRNA classifier (miR-15b and miR-130b) as biomarkers for detection of HCC
| Statistical parameters | Non-cancerous controls (n=59) versus HCCs (n=57) | ||||
| miR-15b (≥43.485 copies/ng) | miR-21 (≥73 271.020 copies/ng) | miR-130b (≥97.250 copies/ng) | miR-183 (≥40.100 copies/ng) | miR-15b + miR-130b (≥−0.6111 sum score) | |
| Sensitivity (%) | 98.25 | 89.47 | 87.72 | 57.89 | 98.25 |
| Specificity (%) | 15.25 | 71.19 | 81.36 | 69.49 | 91.53 |
| False-positive rate (%) | 84.75 | 28.81 | 18.64 | 30.51 | 8.47 |
| False-negative rate (%) | 1.75 | 10.53 | 12.28 | 42.11 | 1.75 |
| Accuracy (%) | 56.03 | 80.17 | 84.48 | 63.79 | 94.83 |
| Positive predictive value (%) | 52.83 | 75.00 | 81.97 | 64.71 | 91.80 |
| Negative predictive value (%) | 90 | 87.50 | 87.27 | 63.08 | 98.18 |
| Positive likelihood ratio | 1.159 | 3.105 | 4.705 | 1.898 | 11.593 |
| Negative likelihood ratio | 0.115 | 0.148 | 0.151 | 0.606 | 0.019 |
| Youden's Index | 0.135 | 0.607 | 0.691 | 0.274 | 0.898 |
| Area under the receiver operating characteristic | 0.485 | 0.865 | 0.913 | 0.661 | 0.981 |
HCC, hepatocellular carcinoma; microRNA, miRNA.