Outcome measure | RCT1 | RCT2 |
Fatigue resistance index (primary outcome measure) |
|
|
Maximum inspiratory pressure |
|
|
Quality of life/functional assessments (Short Form-36, EQ-5D, Acute Care Index of Function) |
|
|
Rate of perceived exertion at rest and during training |
|
|
Duration of mechanical ventilation (days) and duration of weaning (from commencement of pressure-support only to 24 h ventilator-free) | ✓ | NA |
ICU length of stay (days) | ✓ | NA |
Post-ICU discharge length of hospital stay (days) and hospital discharge destination (including in-hospital mortality) | ✓ | ✓ |
ICU readmission rates and reintubation rates (%)—defined as reintubation required within 48 h of extubation | ✓ | ✓ |
Urinary cortisol, creatinine and urea levels |
| NA |
ICU, intensive care unit; NA, not applicable; RCT, randomised controlled trial.