Table 1

Participants with confirmed CMA: primary criterion used to confirm CMA, age at CAP RAST to CM and CAP RAST values and symptoms evoked by the participants' most recent exposure to CMP

Primary criterion to confirm CMAAge (years)CAP RAST to CM (kUA/l)Symptoms evoked after most recent inadvertent CMP intake or DBPCFC to CMP
Positive DBPCFC to CMP within 6 months of study enrolment0.770Pruritus, rash, urticaria/angioedema, rhinorrhoea
0.912.2Pruritus, rash, urticaria/angioedema
1.1<0.35Pruritus, rash
1.3>100Pruritus, rash, urticaria/angioedema
1.49.9Pruritus, rash, urticaria/angioedema
1.615.7Urticaria/angioedema, sneezing/itching, laryngeal oedema
11.612.3Laryngeal oedema
Confirmatory CAP RAST to CM within 6 months of study enrolment0.67.16Pruritus, rash, urticaria/angioedema, wheezing
0.817.1Pruritus, rash, urticaria/angioedema
1.522.4Pruritus, rash, urticaria/angioedema, sneezing/itching
1.634.5Pruritus, rash, vomiting
2.461.8Pruritus, rash, urticaria/angioedema, vomiting
Adverse reaction to inadvertent CMP intake within 6 months and positive CAP RAST to CM within 12 months of study enrolment0.368.3Pruritus, rash, urticaria/angioedema, nasal congestion, sneezing/itching
0.46.09Pruritus, rash, urticaria/angioedema, vomiting
0.54.59Pruritus, rash, urticaria/angioedema, nasal congestion, sneezing/itching
0.610.5Pruritus, rash, urticaria/angioedema, vomiting
0.69.01Pruritus, urticaria/angioedema, nasal congestion, sneezing/itching
0.657.3Pruritus, rash, urticaria/angioedema, nasal congestion, sneezing/itching, laryngeal oedema
0.77.46Pruritus, rash, urticaria/angioedema, nasal congestion, rhinorrhoea, sneezing/itching
0.79.05Pruritus, rash, urticaria/angioedema, rhinorrhoea, sneezing/itching
0.86.84Pruritus, rash, wheezing, vomiting
1.029.1Pruritus, rash, urticaria/angioedema
1.029.5Pruritus, rash, urticaria/angioedema
1.160.8Pruritus, rash, urticaria/angioedema, vomiting
1.3>100Urticaria/angioedema, rhinorrhoea, wheezing, diarrhoea, vomiting
1.423.9Pruritus, rash, urticaria/angioedema, vomiting
1.525.0Pruritus, rash, urticaria/angioedema, vomiting
1.630.5Pruritus, rash, urticaria/angioedema, rhinorrhoea, sneezing/itching
Anaphylaxis to CMP within 6 months and positive CAP RAST to CM within 12 months of study enrolment0.38.01Pruritus, rash, urticaria/angioedema, systemic anaphylaxis
0.45Pruritus, rash, urticaria/angioedema, nasal congestion, rhinorrhoea, sneezing/itching, systemic anaphylaxis
  • * Participant had a history suggestive of CMA beginning at 6 months of age and ongoing symptoms of atopic dermatitis at enrolment.

  • Participant had sufficient evidence of CMA (exhibited multiple symptoms upon inadvertent CM intake within 3 months of enrolment) although CAP RAST to CM was slightly <5 kUA/l.

  • CM, cow's milk; CMA, cow's milk allergy; CMP, cow's milk protein; DBPCFC, double-blind placebo-controlled food challenge.