Table 3

Gender differences in glucose regulation in young adults with very low birth weight

Men (n=42)Women (n=69)p Value
Hyperglycaemia11 (26.2)10 (14.5)0.127
 Diabetes01
 IGT24
 IFG10
 Non-diabetes/IGT/IFG with elevated 1 h glucose levels*85
HbA1c (%)5.39 (5.31 to 5.47)5.39 (5.31 to 5.47)0.635
HOMA-β72.5 (59.0 to 86.0)103 (87.2 to 119.6)0.001
HOMA-IR1.4 (1.14 to 1.69)1.6 (1.29 to 1.90)0.477
Variable during OGTT
 Insulinogenic index1.1 (0.64 to 1.60)1.4 (1.18 to 1.71)0.002
 GlucoseAUC (mmol/l × h)18.8 (17.9 to 19.7)18.2 (17.3 to 19.0)0.089
 InsulinAUC (μU/ml × h)135.3 (98.7 to 171.9)145.1 (121.7 to 168.6)0.052
Reactive hypoglycaemia17 (40)17 (25)0.079
  • * Defined as 1 h glucose levels >8.6 mmol/l.

  • HbA1c, haemoglobin A1c; HOMA-IR, homeostasis model of assessment for insulin resistance; HOMA-β, homeostasis model of assessment for beta cell; IFG, impaired fasting glycaemia; IGT, impaired glucose tolerance; OGTT, oral glucose tolerance test.

  • Data are expressed as mean (95% CI) or n (%).