Oxytocin treatment during labour in cases and controls and crude associations with severe PPH
| Women with severe PPH (N=1483), n (%)* | Controls (N=1758), n (%)* | Crude OR (95% CI) | |
| Oxytocin during labour | 1088 (73) | 1077 (61) | 1.7 (1.5 to 2.0) |
| Oxytocin total dose (IU)† | |||
| Mean (SD) | 2.4 (2.5) | 1.6 (3.0) | |
| Median (25th, 75th pc) | 1.6 (0.6, 3.4) | 0.9 (0.3, 2.0) | |
| No oxytocin | 395 (27) | 681 (42) | Ref |
| <1.0 | 377 (26) | 511 (31) | 1.3 (1.1 to 1.5) |
| 1.0–<2.0 | 229 (16) | 207 (13) | 1.9 (1.5 to 2.4) |
| 2.0–<4.0 | 244 (17) | 157 (10) | 2.7 (2.1 to 3.4) |
| ≥4.0 | 217 (15) | 83 (5) | 4.5 (3.4 to 6.0) |
| MD | 21 (1)‡ | 119 (7)‡ | |
| Maximal infusion rate (mIU/min)† | |||
| Mean (SD) | 9.8 (6.0) | 8.2 (5.3) | |
| Median (25th, 75th pc) | 8.3 (5, 12.5) | 7.5 (5, 10) | |
| No oxytocin | 395 (27) | 681 (42) | Ref |
| <7.5 | 354 (24) | 413 (25) | 1.5 (1.2 to 1.8) |
| 7.5–<10 | 184 (13) | 187 (12) | 1.7 (1.3 to 2.2) |
| 10–<15 | 293 (20) | 213 (13) | 2.4 (1.9 to 2.9) |
| ≥15 | 237 (16) | 128 (8) | 3.2 (2.5 to 4.1) |
| MD | 20 (1)‡ | 136 (8)‡ | |
| Total time of oxytocin infusion (min)† | |||
| Mean (SD) | 295 (187) | 217 (158) | |
| Median (25th, 75th pc) | 266 (150, 408) | 182 (98, 294) | |
| No oxytocin | 395 (27) | 681 (39) | Ref |
| <180 | 342 (23) | 517 (30) | 1.1 (0.9 to 1.4) |
| 180–<300 | 275 (19) | 279 (16) | 1.7 (1.4 to 2.1) |
| 300–<420 | 215 (15) | 158 (9) | 2.3 (1.8 to 3.0) |
| ≥420 | 255 (17) | 100 (6) | 4.4 (3.4 to 5.7) |
| MD | 1 (0.1)‡ | 23 (1)‡ | |
| Time at maximal infusion rate (min)† | |||
| Mean (SD) | 128 (109) | 103 (91) | |
| Median (25th, 75th pc) | 100 (45, 180) | 78 (40, 140) | |
| No oxytocin | 395 (28) | 681 (44) | Ref |
| <90 | 471 (33) | 472 (31) | 1.7 (1.4 to 2.1) |
| 90–150 | 216 (15) | 198 (13) | 1.9 (1.5 to 2.4) |
| 150–210 | 136 (10) | 109 (7) | 2.2 (1.6 to 2.8) |
| ≥210 | 201 (14) | 87 (6) | 4.0 (3.0 to 5.3) |
| MD | 64 (4)‡ | 211 (12)‡ | |