Table 2

Factors influencing survival of MDR/XDRTB patients*

VariableUnadjustedAdjusted*
HR (95% CI)p ValueHR (95% CI)p Value
XDR versus MDR1.29 (0.92 to 1.81)0.151.29 (0.91 to 1.81)0.15
Acquired versus primary1.28 (1.09 to 1.49)0.0021.01 (0.85 to 1.19)0.92
Second-line drug0.39 (0.33 to 0.45)<0.0010.40 (0.34 to 0.47)<0.001
Male sex1.44 (1.18 to 1.76)<0.0011.05 (0.84 to 1.32)0.65
Age
 <301.00<0.0011.00<0.001
 30–393.06 (2.06 to 4.53)2.71 (1.81 to 4.05)
 40–493.81 (2.61 to 5.55)3.14 (2.12 to 4.64)
 50–593.73 (2.54 to 5.48)3.11 (2.09 to 4.63)
 60+5.36 (3.60 to 7.98)4.80 (3.16 to 7.29)
Rural living1.34 (1.16 to 1.55)<0.0011.20 (1.02 to 1.40)0.023
Contact with TB0.58 (0.38 to 0.89)0.0120.93 (0.60 to 1.45)0.75
Smoking1.35 (1.11 to 1.63)0.0020.98 (0.78 to 1.24)0.89
Alcohol
 Didn't use1.01 (0.74 to 1.39)<0.0011.11 (0.78 to 1.58)<0.001
 Sometimes1.001.00
 Often1.87 (1.56 to 2.24)1.52 (1.26 to 1.84)
 Alcoholic1.94 (1.51 to 2.50)1.49 (1.13 to 1.96)
Drug abuse1.35 (0.86 to 2.10)0.191.14 (0.69 to 1.88)0.61
Homelessness1.18 (0.92 to 1.50)0.191.10 (0.84 to 1.44)0.50
Unemployment2.76 (2.04 to 3.75)<0.0011.80 (1.31 to 2.46)<0.001
Education
 Less than primary1.99 (1.49 to 2.67)<0.0011.50 (1.08 to 2.07)0.020
 Prim/secondary1.51 (1.23 to 1.84)1.30 (1.06 to 1.60)
 Tertiary1.001.00
HIV
 Negative1.00<0.0011.00<0.001
 Positive3.93 (2.31 to 6.70)3.44 (1.92 to 6.19)
 Not tested1.55 (1.25 to 1.93)1.60 (1.28 to 2.01)
Co-morbidity0.95 (0.59 to 1.51)0.830.91 (0.56 to 1.46)0.69
TB type
 Pulmonary1.000.651.000.37
 E/pulm0.63 (0.24 to 1.68)1.39 (0.50 to 3.87)
 Both1.00 (0.67 to 1.49)1.30 (0.86 to 1.96)
Cavity1.61 (1.36 to 1.90)<0.0011.54 (1.29 to 1.83)<0.001
Smear positivity1.73 (1.42 to 2.13)<0.0011.47 (1.19 to 1.82)0.001
  • * Values are HRs and CIs from a Cox proportional hazards regression: unadjusted results are not adjusted for any confounders; adjusted results are mutually adjusted for all variables in the table.

  • e/pulm, extrapulmonary tuberculosis; MDR, multidrug resistant ; XDRTB, extensively drug-resistant tuberculosis.