Table 2

Metabolite levels and ratios to creatine in the two areas explored with Magnetic Resonance Spectroscopy

VariableControls (n=35)Converters (n=27)Non-converters (n=44)p Value
Posteromedial parietal cortex
 NAA134 (18.3)120 (19.89)125.8 (15.59)NS
NAA/Cr1.46 (0.08)1.38 (0.09)1.49 (0.08)<0.0001
 Ch/Cr0.61 (0.07)0.62 (0.05)0.59 (0.1)NS
 mI/Cr0.66 (0.08)0.63 (0.08)0.6 (0.09)NS
 NAA/mI2.19 (0.35)2.4 (0.29)2.3 (0.29)NS
Occipital lobe
NAA133.3 (23.1)133.7 (25.1)146.9 (24.4)0.03
NAA/Cr1.65 (0.08)1.49 (0.08)1.6 (0.08)<0.0001
 Ch/Cr0.6 (0.07)0.55 (0.05)0.57 (0.07)NS
 mI/Cr0.65 (0.1)0.59 (0.06)0.6 (0.07)NS
 NAA/mI2.52 (0.36)2.63 (0.29)2.61 (0.4)NS
  • Statistical significance refers to the differences found between converters and non-converters. Statistical significance is represented by the p value on the right column

  • Ch, choline; Cr, creatine; mI, myo-inositol; NAA, N-acetyl-aspartate; NS, not significant.