Table 4

Samples to be collected from the participant

Human biological specimens and
screening tests		Enrollment/baselineMonth 3Month 6
4 mL blood (1 pc 4 mL red-top tube)
Screening test:

  • RPR

✓
✓
15 mL blood (3 pcs 5 mL gold-top tube)
Screening tests:

  • SGPT / ALT (KINETIC)

  • SGOT / AST (KINETIC)

  • Vit B12 (ECLIA)

  • FT4

  • TSH

✓
✓
✓
✓
✓
✓
30 mL urine for urinalysis✓
Fresh stool sample for fecalysis✓
8 mL blood (2 pcs 4 mL purple-top tube) for omics analysis✓✓✓
8 mL blood (2 pcs 4 mL red-top tube) for omics analysis✓✓✓
30 mL urine for omics analysis✓✓✓
Stool obtained from OMNIgene·GUT | OM-200 for microbiome analysis✓✓✓
Stool obtained from OMNImet·GUT | ME-200 for metabolomics analysis✓✓✓

  • ALT, alanine aminotransferase; FT4, free thyroxine; RPR, rapid plasma reagin; SGOT, serum glutamic-oxaloacetic transaminase; SGPT, serum glutamic pyruvic transaminase; TSH, thyroid-stimulating hormone.