Total number scanned for amyloid=316 Number randomised=88 Number of completers=75 (=88×0.86) | Power estimate* assuming tau PET mean annual change (SD) of 0.05 (0.04)† when untreated | Power estimate* assuming tau PET mean annual change (SD) of 2.01 (2.97)‡ when untreated | ||

One-year change from baseline in mean tau accumulation with semaglutide | Alpha 0.05 | Alpha 0.10 | Alpha 0.05 | Alpha 0.10 |

20% lower compared with placebo. Effect differences of 0.01 and 0.402, respectively | 19.7% | 29.9% | 9.2% | 16.0% |

30% lower compared with placebo. Effect differences of 0.015 and 0.603, respectively | 38.1% | 50.8% | 14.6% | 23.4% |

40% lower compared with placebo. Effect differences of 0.02 and 0.804, respectively | 59.8% | 71.6% | 22.3% | 33.0% |

316 individuals need to be screened to randomise 88 participants, with 75 participants completing the study, assuming a 14% dropout rate.

*Power calculation is based on a two-sample t-test assuming equal variance.

†Hanseeuw, BJ

*et al*.32 2019 PMID: 31157827.‡Whittington A, Gunn R.33 2021 PMID: 33517326.