Table 2

(A and B) Baseline characteristics stratified by the presence or absence of an ICE (A) and stratified by the IAC consensus (B)

N (%) for categorical variables, median (IQR) for continuousICENo ICEP value
N=41N=34
Age, years9.8 (6.6, 12.1)9.0 (6.2, 12.9)0.87
Weight, kilogram32.0 (22.6, 40.5)28.0 (19.1, 38.1)0.65
Fever duration, days3.0 (1.0, 4.0)2.5 (1.0, 4.0)0.53
Any inotropes19 (46.3)6 (17.6)0.02
Lymphocytes, G/L0.66 (0.47, 1.03)1.00 (0.64, 1.42)0.04
Platelets, G/L127.00 (100.25, 166.00)179.50 (142.25, 260.75)0.004
D-dimers, µg/L4249.50 (1868.00, 6355.75)1840.00 (1233.50, 3491.25)0.01
Ferritin, µg/L679.00 (447.25, 1095.75)247.00 (194.00, 488.00)<0.001
C- reactive protein, mg/L169.50 (115.30, 230.65)140.50 (90.12, 199.00)0.13
Troponin, ng/L11.00 (6.00, 25.80)24.00 (16.00, 55.10)0.05
NTproBNP, pg/mL2418.50 (807.75, 7281.00)3330.00 (924.50, 7130.50)0.77
N (%) for categorical variables, median (IQR) for continuousICE indicatedICE non-indicatedP value
N=27N=14
Age, years9.4 (8.1, 11.3)10.7 (6.2, 12.1)0.98
Weight, kilogram32.2 (23.9, 37.8)32.0 (22.8, 41.8)0.99
Fever duration, days1.0 (1.0, 2.0)3.0 (2.0, 5.0)0.02
Any inotropes5 (35.7)14 (51.9)0.51
Lymphocytes, G/L0.80 (0.70, 1.41)0.62 (0.45, 0.79)0.11
Platelets, G/L116.50 (99.75, 133.25)137.00 (101.50, 177.00)0.31
D-Dimers, µg/L2440.00 (1834.50, 5310.25)4458.50 (2306.75, 6747.25)0.27
Ferritin, µg/L549.00 (444.00, 588.00)816.00 (552.00, 1297.00)0.08
C-reactive protein, mg/L137.00 (111.50, 230.30)182.30 (117.20, 235.50)0.66
Troponin, ng/L13.00 (8.00, 34.00)10.50 (5.25, 25.00)0.69
NTproBNP, pg/mL3212.50 (1360.75, 7683.50)1628.00 (697.00, 7199.50)0.51
  • A: Difference in baseline characteristics for patients with and without ICEs in lymphocytopaenia, thrombocytopaenia, ferritin, D-dimers and need for inotropic support.

  • B: Difference in baseline characteristics for patients with a clinically indicated vs non-indicated ICE in longer fever duration.

  • IAC, independent adjudication committee; ICE, intercurrent event; NTproBNP, N-Terminal Pro-B-Type Natriuretic Peptide.