Table 2

Neurological criteria to diagnose CIP, CIM or CIP/CIM

DiagnosisCriteria
CIPReduced SNAP amplitudes
(Or reduced SNAP and/or neCMAP/dmCMAP ratio <0.5 and unspecific findings (pathological spontaneous muscle activity and reduced neCMAP))
CIMReduced dmCMAP (<3 mV) or reduced MUAP duration
(Or reduced dmCMAP of at least one muscle and unspecific findings (pathological spontaneous muscle activity and reduced neCMAP) and normal sensory and motor nerve conduction velocity)
CIP/CIMReduced neCMAP and abnormal spontaneous muscle activity
(Or reduced dmCMAP and reduced SNAP and/or neCMAP/dmCMAP ratio <0.5)
UnspecificPathological spontaneous muscle activity and reduced neCMAP
  • CIM, critical illness myopathy; CIP, critical illness polyneuropathy; dmCMAP, compound muscle action potential after direct muscle stimulation; MUAP, motor unit action potential; neCMAP, compound muscle action potential after nerve stimulation; SNAP, sensory nerve action potential.