Table 1

Outcomes and measurements

Outcome	Level	Mode of data collection	Timing of data collection
Implementation outcomes
Appropriateness	Neonatal providers	Virtual focus groups	Preimplementation and postimplementation of VIGOR at participating sites
Feasibility	Neonatal providers	Virtual focus groups	Preimplementation and postimplementation of VIGOR at participating sites
Penetration	Infant	Tracking rapid ES report, CIR and disclosure	Throughout enrolment period
Service outcomes
Equity	Infant	Tracking rapid ES report, CIR and disclosure, as well as chart abstraction	Throughout enrolment period
Client outcomes
Function (provider) Comfort with genomic medicine	Neonatal providers	Survey	Pregenomic and postgenomic education survey
Function (family) Mental health	Family	Survey	At enrolment and 3, 6 and 12 months after results disclosure
Symptomatology Neonatal clinical outcomes	Infant	Chart abstraction	At NICU discharge/transfer and 12 months after results disclosure
Symptomatology Neonatal clinical outcomes	Infant	Survey	3, 6 and 12 months after results disclosure
Satisfaction (provider) With disclosure process and the VIGOR study	Neonatal provider	Survey	After each results disclosure
		Qualitative interviews	After 3–5 disclosure events
		Virtual focus groups	Postimplementation of VIGOR at participating sites
Satisfaction (family) With disclosure process and participation in VIGOR	Family	Survey	Within 2 weeks of results disclosure
	Family	Qualitative interviews (with subset)	Within 2 months of results disclosure

CIR, clinical interpretive report; ES, exome sequencing; NICU, neonatal intensive care unit; VIGOR, VIrtual GenOme CenteR.