Table 4

Association between the number of clinicians declaring financial conflicts of interest (FCOIs) and supporting evidence for positive group recommendations*

Clinical gainsConflict with submissionConflict with another companyNo conflictP value
ESMO-MCBS score
 Substantial benefit8434450.1
 No substantial benefit653460
OS benefit
 Improved5631380.29
 Not improved401225
HRQoL status
 Improved2612220.77
 Worsened12412
  • *FCOI status is defined as the number of clinicians declaring an FCOI that participated in the drug submission process; positive clinician funding recommendations include partial agreement with positive CADTH recommendation; total values differ between supporting evidence categories due to data availability of the clinical gain; association between FCOI status and clinical gains was analysed using Fisher’s exact test.

  • CADTH, Canadian Agency for Drugs and Technology in Health; ESMO-MCBS, European Society for Medical Oncology Magnitude of Clinical Benefit Scale; HRQoL, health-related quality of life; OS, overall survival.