Table 3

Multivariable COX proportional hazard regression models of time to event

Time to extubationTime to ICU dischargeTime to in-hospital death
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
Trajectory group      
 Group 10.23 (0.16 to 0.32)<0.0010.36 (0.26 to 0.51)<0.00113.62 (5.99 to 30.95)<0.001
 Group 20.30 (0.23 to 0.41)<0.0010.44 (0.33 to 0.59)<0.0015.62 (2.36 to 13.38)<0.001
 Group 30.72 (0.59 to 0.87)<0.0010.80 (0.65 to 0.97)0.0241.76 (0.76 to 4.08)0.185
 Group 4Reference Reference Reference 
Age      
 20–29Reference Reference Reference 
 30–391.08 (0.53 to 2.21)0.8250.70 (0.35 to 1.42)0.3340.69 (0.06 to 7.72)0.765
 40–490.89 (0.43 to 1.81)0.7480.63 (0.31 to 1.25)0.1880.59 (0.06 to 5.28)0.641
 50–591.04 (0.53 to 2.03)0.8930.65 (0.34 to 1.23)0.1920.41 (0.04 to 3.46)0.414
 60–691.00 (0.52 to 1.93)0.9870.79 (0.42 to 1.48)0.4690.88 (0.11 to 6.75)0.905
 70–791.04 (0.54 to 1.99)0.8930.64 (0.34 to 1.20)0.1700.47 (0.06 to 3.65)0.473
 ≥800.85 (0.44 to 1.64)0.6320.53 (0.28 to 1.00)0.0520.82 (0.10 to 6.26)0.850
Female0.85 (0.71 to 1.01)0.0750.98 (0.81 to 1.17)0.8481.17 (0.73 to 1.89)0.50
Type of admission      
 MedicalReference Reference Reference 
 Emergency surgery1.02 (0.79 to 1.32)0.8391.17 (0.90 to 1.53)0.2341.35 (0.62 to 2.91)0.444
 Scheduled surgery2.13 (1.64 to 2.78)<0.0012.10 (1.59 to 2.78)<0.0011.91 (0.87 to 4.16)0.102
Type of ICU      
 Medical ICUReference Reference Reference 
 Surgical ICU1.05 (0.83 to 1.33)0.6290.87 (0.68 to 1.12)0.2990.45 (0.23 to 0.89)0.021
 Others1.53 (0.96 to 2.40)0.0681.28 (0.80 to 2.06)0.2890.55 (0.12 to 2.47)0.441
Vasopressor infusions0.85 (0.69 to 1.04)0.1160.85 (0.69 to 1.04)0.1221.25 (0.62 to 2.51)0.529
Neuromuscular blockade1.05 (0.86 to 1.28)0.5860.88 (0.72 to 1.07)0.2171.42 (0.88 to 2.29)0.148

  • Hazard ratio >1 indicates a higher probability of event than reference.

  • ICU, intensive care unit.