Antibiotic | Administration* | Standard dose* | Frequency* | Dose adjustment* |
Penicillin | ||||
Mecillinam | IV | 800–1000 mg | Every 8 hours | – |
Pivmecillinam | PO | 800 mg | Every 8 hours | – |
Amoxicillin/clavulanate | PO | 1000 mg/250 mg | Every 6 hours | Renal impairment and weight |
Pipercillin/tazobactam | IV | 4 g/0.5 g | Every 6 or 8 hours | Renal impairment and weight |
Ampicillin | IV | 2 g | Every 6 or 8 hours | Renal impairment and weight |
Pivampicillin | PO | 500 mg | Every 6 or 8 hours | Renal impairment and weight |
Amoxicillin | PO | 1 g | Every 6 or 8 hours | Renal impairment and weight |
Cephalosporin | ||||
Cefuroxime | IV | 1.5 g | Every 8 hours | Renal impairment and weight |
Cefuroxime | PO | 500 mg | Every 12 hours | Renal impairment and weight |
Cefotaxime | IV | 1 g | Every 8 hours | Renal impairment and weight |
Ceftazidime | IV | 1 g | Every 8 or 12 hours | Renal impairment and weight |
Ceftriaxone | IV | 2 g | Every 24 hours | Renal and hepatic impairment and weight |
Carbapenem | ||||
Meropenem | IV | 1 g | Every 8 hours | Renal impairment and weight |
Ertapenem | IV | 1 g | Every 24 hours | – |
Aminoglycoside | ||||
Gentamicin/tobramycin | IV | 5–7 mg/kg | Every 24 hours | Renal impairment and weight |
Fluoroquinolone | ||||
Ciprofloxacin | IV | 400 mg | Every 12 hours | Renal impairment and weight |
Ciprofloxacin | PO | 500–750 mg | Every 12 hours | Renal impairment and weight |
Sulfamethizole | PO | 1 g | Every 12 hours | Renal impairment and weight |
Nitrofurantoin | PO | 100 mg | Every 6 hours | Renal impairment and weight |
Trimethoprim | PO | 200 mg | Every 12 hours | Renal impairment and weight |
Sulfamethoxazole/trimethoprim | PO | 800 mg/160 mg | Every 12 hours | Renal impairment and weight |
*Standard recommendation.
IV, intravenous; PO, orally.