Association between single PAH and PHTHTE body burden scores and rheumatoid arthritis
| Variable | Adjustment 1 | Adjustment 2 | ||
| OR (95% CI) | P value | OR (95% CI) | P value | |
| PAH body burden* | ||||
| Quartile 2 vs 1 | 1.5 (0.91 to 2.4) | 0.11 | 1.5 (0.87 to 2.5) | 0.15 |
| Quartile 3 vs 1 | 1.9 (1.2 to 3.1) | 0.012 | 1.7 (0.97 to 3.0) | 0.066 |
| Quartile 4 vs 1 | 2.6 (1.5 to 4.4) | <0.001 | 2.2 (1.09 to 4.2) | 0.028 |
| PHTHTE body burden† | ||||
| Quartile 2 vs 1 | 1.6 (1.00 to 2.6) | 0.052 | 1.6 (0.91 to 2.6) | 0.10 |
| Quartile 3 vs 1 | 1.6 (0.99 to 2.5) | 0.056 | 1.4 (0.82 to 2.4) | 0.21 |
| Quartile 4 vs 1 | 1.8 (1.06 to 2.9) | 0.030 | 1.6 (0.89 to 2.8) | 0.12 |
PHTHTE body burden score includes: mono-2-ethyl-5-carboxypentyl phthalate, mono-n-butyl phthalate, mono-ethyl phthalate, mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-isobutyl phthalate, mono-(2-ethyl-5-oxohexyl) phthalate, mono-benzyl phthalate, mono(carboxynonyl) phthalate, mono(carboxyoctyl) phthalate and mono-(3-carboxypropyl) phthalate.
Adjustment 1: adjusted for age and sex (male vs female).
Adjustment 2: adjusted for age, sex (male vs female), body mass index, urine creatinine, smoking (never vs past vs current), race (non-Hispanic white vs non-Hispanic black vs Mexican-American vs other), education (high school or less vs more than high school), family poverty income ratio, any vigorous or moderate activity (yes vs no) and dietary fibre.
All models were fitted on each of the five imputed datasets and parameter estimates were combined using SAS MIANALYZE.
Bold indicates the significant with p<0.05.
*PAH subset (n=7090) with PAH subsample weights used for analysis. PAH body burden score includes: 1-hydroxynaphthalene, 2-hydroxynaphthalene, 3-hydroxyfluorene, 2-hydroxyfluorene, 1-hydroxyphenanthrene and 1-hydroxypyrene.
†PHTHTE subset (n=7024) with PHTHTE subsample weights used for analysis.
PAH, polycyclic aromatic hydrocarbons; PIR, poverty income ratio.