Baseline characteristics of patients contributing data to the IPD meta-analysis
| CRASH-2 | WOMAN | CRASH-3 | HALT-IT | All | |
| Randomised (N) | 20 211 | 20 060 | 12 737 | 12 009 | 65 017 |
| Contributing IPD (N) | 20 127 | 20 021 | 12 639 | 11 937 | 64 724 |
| Time to treatment (%) | |||||
| ≤3 | 13 485 (67) | 14 928 (75) | 9127 (72) | 1926 (16) | 39 466 (61) |
| 3–8 | 6613 (33) | 3637 (18) | 3474 (28) | 3136 (26) | 16 860 (26) |
| >8 | 21 (0.1) | 1446 (7) | 38 (0.3) | 6874 (58) | 8379 (13) |
| Missing | 8 (0) | 10 (0) | 0 (0) | 1 (0) | 19 (0) |
| Mean (SD) | 2.8 (2.4) | 3.4 (23.4) | 2.9 (2.8) | 21.9 (36.8) | 6.5 (21.8) |
| Median (IQR) | 2 (1-4) | 1.1 (.5–3.1) | 2.4 (1.6–3.5) | 11 (5–24) | 2.4 (1–5) |
| Age | |||||
| <20 | 2142 (11) | 1021 (5) | 956 (8) | 110 (1) | 4229 (7) |
| 20–39 | 11 666 (58) | 18 312 (91) | 5266 (42) | 1455 (12) | 36 699 (57) |
| 40–59 | 4869 (24) | 681 (3) | 3399 (27) | 4664 (39) | 13 613 (21) |
| 60–79 | 1315 (7) | 0 (0) | 2279 (18) | 4184 (35) | 7778 (12) |
| ≥80 | 134 (1) | 0 (0) | 739 (6) | 1524 (13) | 2397 (4) |
| Missing | 1 (0) | 7 (0) | 0 (0) | 0 (0) | 8 (0) |
| Mean (SD) | 34.6 (14.3) | 28.3 (5.7) | 43.1 (19.8) | 58 (17) | 38.6 (17.7) |
| Median (IQR) | 30 (24–43) | 28 (24–32) | 40 (25–58) | 58 (46–70) | 33 (25–50) |
| SBP | |||||
| <75 | 3042 (15) | 1606 (8) | 59 (0) | 327 (3) | 5034 (8) |
| 75–90 | 7004 (35) | 5853 (29) | 478 (4) | 2426 (20) | 15 761 (24) |
| >90 | 10 052 (50) | 12 557 (63) | 12 062 (95) | 9149 (77) | 43 820 (68) |
| Missing | 29 (0) | 5 (0) | 40 (0) | 35 (0) | 109 (0) |
| Mean (SD) | 97.0 (27.9) | 100.8 (22.7) | 130.6 (26.3) | 111.1 (23.6) | 107.4 (28.2) |
| Median (IQR) | 91 (80–110) | 100 (90–110) | 129 (110–145) | 110 (95–125) | 100 (90–121) |
IPD, individual patient data; SBP, systolic blood pressure.