Characteristics of pregnant women with COVID-19
All patients (n=1043) | Severe cases (n=56) | Non-severe cases (n=987) | P value | ||||
n | % | n | % | n | % | ||
Maternal age* | |||||||
Median (IQR) (years) | 30 | 26–34 | 33 | 29–38 | 30 | 26–34 | <0.0001 |
Under 20 | 15 | 1.4 | 0 | 0.0 | 15 | 1.5 | 1.00 |
20–29 | 471 | 45.2 | 14 | 25.0 | 457 | 46.4 | 0.002 |
30–39 | 501 | 48.1 | 34 | 60.7 | 467 | 47.4 | 0.05 |
Over 40 | 54 | 5.2 | 8 | 14.3 | 46 | 4.7 | 0.002 |
Characteristic | |||||||
Nulliparous† | 480 | 46.6 | 22 | 39.3 | 458 | 47.1 | 0.26 |
Multiple pregnancy‡ | 17 | 1.7 | 3 | 5.7 | 14 | 1.5 | 0.06 |
Pregnancy period at diagnosis | |||||||
Median (IQR) (weeks) | 26 | 16–33 | 32 | 26–35 | 25 | 15–33 | <0.0001 |
First trimester | 202 | 19.4 | 1 | 1.8 | 201 | 20.4 | <0.0001 |
Second trimester | 380 | 36.4 | 15 | 26.8 | 365 | 37.0 | 0.12 |
Third trimester | 461 | 44.2 | 40 | 71.4 | 421 | 42.7 | <0.0001 |
Epidemiological history | |||||||
Familial infection | 537 | 51.5 | 28 | 50.0 | 509 | 51.6 | 0.82 |
Community acquired | 164 | 15.7 | 10 | 17.9 | 154 | 15.6 | 0.65 |
Nosocomial infection | 18 | 1.7 | 1 | 1.8 | 17 | 1.7 | 1.00 |
Workplace infection | 50 | 4.8 | 1 | 1.8 | 49 | 5.0 | 0.51 |
Unknown | 274 | 26.3 | 16 | 28.6 | 258 | 26.1 | 0.69 |
Comorbidities§ | |||||||
Diabetes | 8 | 0.8 | 2 | 3.6 | 6 | 0.6 | 0.07 |
Chronic hypertension | 7 | 0.7 | 2 | 3.6 | 5 | 0.5 | 0.05 |
Asthma | 36 | 3.5 | 4 | 7.1 | 32 | 3.3 | 0.13 |
Body mass index>25 | 37 | 3.6 | 5 | 8.9 | 32 | 3.3 | 0.045 |
Pregnancy complications‡ | |||||||
Hypertensive disorders of pregnancy | 19 | 1.9 | 2 | 3.8 | 17 | 1.8 | 0.27 |
HELLP syndrome | 3 | 0.3 | 0 | 0.0 | 3 | 0.3 | 1.00 |
Gestational diabetes mellitus | 40 | 4.0 | 5 | 9.4 | 35 | 3.7 | 0.06 |
Placental abruption | 3 | 0.3 | 1 | 1.9 | 2 | 0.2 | 0.15 |
Deep venous thrombosis | 1 | 0.1 | 0 | 0.0 | 1 | 0.1 | 1.00 |
Course of pregnancy | |||||||
Pregnancy ongoing | 192 | 18.4 | 5 | 8.9 | 187 | 18.9 | 0.07 |
Delivery | 526 | 50.4 | 41 | 73.2 | 485 | 49.1 | 0.001 |
Delivery during infection | 164 | 15.7 | 28 | 50.0 | 136 | 13.8 | <0.0001 |
Spontaneous abortion | 12 | 1.2 | 0 | 0.0 | 12 | 1.2 | 1.00 |
Induced abortion | 4 | 0.4 | 0 | 0.0 | 4 | 0.4 | 1.00 |
Stillbirth | 1 | 0.1 | 0 | 0.0 | 1 | 0.1 | 1.00 |
Unknown | 308 | 29.5 | 10 | 17.9 | 298 | 30.2 | 0.05 |
Data are presented as n (%) or median (IQR). The p value is a comparison of severe and non-severe cases.
*Excluding 2 cases with missing data
†Excluding 14 cases with missing data
‡Excluding 47 cases with missing data
§Excluding 10 cases with missing data
HELLP, Hemolysis, elevated liver enzymes, and low platelet count.