Table 3

Variables available at baseline, and at 6 and 12 months follow-up within the FOCUS Consortium

Category	Variables	Baseline	6 months	12 months
Demographics	Age	x	x	x
	Gender	x
	Highest education	x
	Social status	x
	Height	x
	Weight	x	x	x
	BMI	x	x	x
	Smoking status	x	x	x
	Smoking duration	x	x	x
	Smoking pack years	x	x	x
	Menopausal status	x
	Postmenopausal hormone use	x
	Race	x
Cancer characteristics	Cancer site	x
	Cancer stage	x
	TNM classification	x
Treatment	Preoperative chemotherapy	x
	Preoperative radiotherapy	x
	Surgery	x	x
	Postoperative chemotherapy		x	x
	Postoperative radiotherapy		x	x
Supplement intake	Folic acid supplements	x	x	x
	Vitamin B₂ supplements	x	x	x
	Vitamin B₆ supplements	x	x	x
	Vitamin B₁₂ supplements	x	x	x
	Vitamin A supplements	x	x	x
	Vitamin C supplements	x	x	x
	Vitamin D supplements	x	x	x
(Supplement intake	Vitamin E supplements	x	x	x
	Calcium supplements	x	x	x
	Magnesium supplements	x	x	x
	Iron supplements	x	x	x
	Multivitamins	x	x	x
Dietary nutrients	Folate equivalents	x	x	x
	Vitamin B₂	x	x	x
	Vitamin B₆	x	x	x
	Vitamin B₁₂	x	x	x
	Vitamin A	x	x	x
	Vitamin C	x	x	x
	Vitamin D	x	x	x
	Vitamin E	x	x	x
	Total protein	x	x	x
	Total fat	x	x	x
	Total carbohydrate	x	x	x
Dietary nutrients	Fibre	x	x	x
	Saturated fatty acids	x	x	x
	Monounsaturated fatty acids	x	x	x
	Polyunsaturated fatty acids	x	x	x
	Alcohol	x	x	x
	Total energy	x	x	x
Physical activity	Light physical activity	x	x	x
	Moderate physical activity	x	x	x
	Vigorous physical activity	x	x	x
	Adherence to physical activity guidelines	x	x	x
Medical history	Diabetes mellitus	x	x	x
	Asthma, chronical bronchitis, COPD, emphysema	x
	Heart attack, heart failure	x
	Hypertension	x
	Stroke	x
	Ulcer of stomach or duodenum	x
	Hypothyroidism/hyperthyroidism	x
	Systemic lupus erythematosus	x
	Inflammatory bowel disease (Crohn’s disease, ulcerative colitis)	x
	Familial adenomatous polyposis	x
Medical history	Lynch syndrome (hereditary nonpolyposis colorectal cancer)	x
Regular medication use	Aspirin	x	x	x
	NSAID	x	x	x
	Ibuprofen	x	x	x
	Naproxen	x	x	x
	Celecoxib/etoricoxib	x	x	x
Health-related quality of life	EORTC QLQ-C30	x	x	x
	EORTC QLQ-CR29	x	x	x
	EORTC QLQ-CIPN20	x	x	x
General information	Date of questionnaire completion	x	x	x
	Date of blood collection	x	x	x
	Freeze-thaw cycles of blood samples	x	x	x
	Haemolysis	x	x	x
	Time between blood draw and processing/storage	x	x	x

BMI, body mass index; C30, core 30-items; CIPN20, chemotherapy-induced polyneuropathy 20-items.; COPD, Chronic Obstructive Pulmonary Disease; CR29, colon/rectum 29-items; EORTC, European Organisation for Research and Treatment of Cancer; NSAID, non-steroidal anti-inflammatory drug; QLQ, quality of life questionnaire; TNM, tumor, nodes, and metastases.