Inclusion criteria | Exclusion criteria |
T1D with C-peptide <200 pmol/L | Current use of non-approved closed loop system or predictive low glucose suspend insulin pump |
Age 21–65 years | Regular use of real-time CGM in the preceding 3 months |
T1D for ≥5 years | History of DKA in the preceding 6 months |
HbA1c ≥53 mmol/mol | Inability to safely use the technology in this study |
Normal renal function | History of:
|
Normal thyroid function | Unable to adhere to study timetable |
Willingness to monitor blood ketones daily | Unable to give informed consent |
Use of freestyle libre device permitted in group 1 | Concurrent use of non-insulin glucose lowering agents (GLP-1 agonists, Symlin, DPP-4 inhibitors, SGLT-2 inhibitors, sulphonylureas) |
Concurrent use of SSRIs or other medication that effects blood glucose | |
A condition, which in the opinion of the investigator, would put the patient or study at risk | |
Pregnant or planning a pregnancy | |
Proliferative retinopathy | |
HbA1c ≥75 mmol/mol |
CGM, continuous glucose monitoring; DKA, diabetic ketoacidosis; SSRI, selective serotonin reuptake inhibitor; T1D, type 1 diabetes.